Findings

What do systematic reviews say?

6 questions · 7 findings · 4 reviews · Neonatal

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 2 · 28.6%Moderate 4 · 57.1%High 0 · 0%

Inhaled steroids vs systemic corticosteroids

Death or BPD (28 days) · preterm infants with respiratory distress for initial respiratory support

Inhaled steroids showed no clear difference in death or BPD at 28 days compared with systemic corticosteroids (low certainty).

1 finding from 1 review

Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight… 2017 · Cochrane Headline outcomes only
RR 1.05 [0.93, 1.2]
2 studies · 294 participants
Low

Inhaled steroids vs systemic corticosteroids

BPD or death at 36 weeks' postmenstrual age№ of participants: 0 (0 RCTs) · preterm infants with respiratory distress for initial respiratory support

Inhaled steroids showed no clear difference in death or BPD at 36 weeks' postmenstrual age among all randomised compared with systemic corticosteroids (moderate certainty).

1 finding from 1 review

Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight… 2017 · Cochrane Headline outcomes only
RR 1.09 [0.88, 1.35]
1 study · 278 participants
Moderate

Adjunctive steroid vs placebo

Death at hospital discharge · neonates with clinical and microbiological features of bacterial meningitis

It is very uncertain whether adjunctive steroid changes all‐cause death until hospital discharge compared with placebo (very low certainty).

1 finding from 1 review

Adjuvant corticosteroids for reducing death in neonatal bacterial meningitis 2015 · Cochrane Headline outcomes only
RR 0.46 [0.24, 0.88]
2 studies · 132 participants
Very low

Inhaled steroids vs systemic steroids

Death or bronchopulmonary dysplasia at 36 weeks PMA · Neonates with developing BPD

Inhaled steroids showed no clear difference in death or BPD at 36 weeks' postmenstrual age compared with systemic steroids (moderate certainty).

2 findings from 1 review

Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth… 2017 · Cochrane Headline outcomes only
RR 1.04 [0.86, 1.26]
1 study · 292 participants
Moderate
Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth… 2017 · Cochrane Headline outcomes only
RR 0.94 [0.83, 1.05]
1 study · 78 participants
Low

Inhaled steroids vs systemic steroids

Death or moderate/severe disability at 7 years · Neonates with developing BPD

Inhaled steroids showed no clear difference in death or moderate/severe disability at 7 years compared with systemic steroids (moderate certainty).

1 finding from 1 review

Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth… 2017 · Cochrane Headline outcomes only
RR 1.01 [0.65, 1.58]
1 study · 107 participants
Moderate

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36 weeks' PMA · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) probably leads to lower death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36… compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review

Early administration of inhaled corticosteroids for preventing chronic lung disease in very low birth weight preterm… 2017 · Cochrane Headline outcomes only
RR 0.86 [0.75, 0.99]
6 studies · 1285 participants
Moderate