Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

191 questions · 192 findings · 60 reviews

No studies found 43 · 22.4%GRADE not reported 14 · 7.3%Very low 54 · 28.1%Low 44 · 22.9%Moderate 28 · 14.6%High 9 · 4.7%

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

Death associated with fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole,… showed no clear difference in death associated with fungal infection compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs Antifungal drugs not absorbed from GI tract

Death associated with fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract showed no clear difference in death associated with fungal infection compared with antifungal drugs not absorbed from GI tract; GRADE not reported.

1 finding from 1 review

Antifungal drugs not absorbed from GI tract vs placebo or no treatment

Death associated with fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs not absorbed from GI tract showed no clear difference in death associated with fungal infection compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes adverse events: death (secondary outcome) compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

CKD or death: 50% decline in GFR by 78 weeks · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in CKD or death: 50% decline in GFR by 78 weeks compared with mycophenolate mofetil with pulse dexamethasone (low certainty).

1 finding from 1 review

Joint crisis plan plus treatment as usual vs treatment

Deatha Timing of outcome assessment: 12 months · community‐dwelling adults with a diagnosis of borderline personality disorder

Joint crisis plan plus treatment as usual showed no clear difference in deatha Timing of outcome assessment: 6 months compared with treatment (low certainty).

1 finding from 1 review

Brief admission to psychiatric hospital by self‐referral plus treatment as usual vs treatment

Deatha Timing of outcome assessment: 12 months · adults meeting 3 or more diagnostic criteria for borderline personality disorder

Brief admission to psychiatric hospital by self‐referral plus… showed no clear difference in deatha Timing of outcome assessment: 12 months compared with treatment (low certainty).

1 finding from 1 review

Enteral nutrition via nasojejunal tube plus intravenous glutamine‐dipeptide supplementation vs parenteral nutrition

All‐cause mortality during hospital stay · adult patients after liver transplantation.

It is very uncertain whether enteral nutrition via nasojejunal tube plus intravenous… changes death (during length of initial hospital stay; ITT) compared with standard parenteral nutrition (very low certainty).

1 finding from 1 review

Azathioprine vs methotrexate

Adverse event causing death or study drug discontinuation · adults with renal vasculitis for maintenance therapy

Azathioprine showed no clear difference in adverse events causing death or study drug discontinuation compared with methotrexate (low certainty).

1 finding from 1 review

Intervention not reported

Patient outcome: death, disability or dependency at 90 days · health professionals providing care to patients with stroke

The intervention showed no clear difference in patient outcome: death, disability or dependency at 90 days (moderate certainty).

1 finding from 1 review

Psychological therapy vs usual care or attention control

Adverse events: death ‐ at end of treatment (Analysis 1.14) · people with stroke

It is very uncertain whether psychological therapy changes adverse events: death ‐ at end of treatment (Analysis 2.16) compared with usual care and/or attention control (very low certainty).

1 finding from 1 review