Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

28 questions · 32 findings · 15 reviews · Gynaecology and Fertility

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 10 · 31.3%Low 17 · 53.1%Moderate 5 · 15.6%High 0 · 0%

Subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist vs placebo/no treatment

Clinical pregnancy rate · women trying to conceive by intrauterine insemination

It is very uncertain whether subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist changes clinical pregnancy rate compared with placebo/no treatment (very low certainty).

1 finding from 1 review

GnRH agonists vs placebo

Clinical pregnancy rate · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

It is very uncertain whether among different GnRH agonists changes clinical pregnancy rate compared with placebo (very low certainty).

1 finding from 1 review

Metformin vs placebo or no treatment

Clinical pregnancy rate · women with polycystic ovary syndrome

It is very uncertain whether metformin changes clinical pregnancy rate per woman ‐ short protocol GnRH‐antagonist compared with placebo or no treatment (very low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin vs placebo or no treatment

Clinical pregnancy rate · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Metformin probably leads to higher clinical pregnancy rate per woman compared with placebo or no treatment (moderate certainty).

1 finding from 1 review