Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

19 questions · 23 findings · 8 reviews · Gynaecology and Fertility

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 9 · 39.1%Low 8 · 34.8%Moderate 6 · 26.1%High 0 · 0%

Metformin vs placebo or no treatment

Clinical pregnancy rate · women with polycystic ovary syndrome

It is very uncertain whether metformin changes clinical pregnancy rate per woman ‐ short protocol GnRH‐antagonist compared with placebo or no treatment (very low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin vs placebo or no treatment

Clinical pregnancy rate · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Metformin probably leads to higher clinical pregnancy rate per woman compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Metformin vs clomiphene

Clinical pregnancy rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome

Metformin may leads to lower clinical pregnancy rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin vs clomiphene

Clinical pregnancy rate per woman Participants with BMI < 30 kg/m2 or ≤ 32 kg/m2a · women with polycystic ovary syndrome

Metformin may leads to higher clinical pregnancy rate per womanaParticipants with BMI < 30 kg/m2… compared with clomiphene citrate (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin combined with clomiphene citrate vs clomiphene

Clinical pregnancy rate · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate probably leads to higher clinical pregnancy rate per woman compared with clomiphene citrate alone (moderate certainty).

2 findings from 2 reviews · compare the 2 reviews

G‐CSF vs no treatment or placebo

Clinical pregnancy rate ‐ women with thin endometrium · Subfertile women undergoing assisted reproduction

G‐CSF showed no clear difference in clinical pregnancy rate ‐ women with thin endometrium compared with no treatment or placebo (low certainty).

1 finding from 1 review

Long‐term GnRH agonist therapy vs no additional therapy

Clinical pregnancy rate · patients with endometriosis prior to standard IVF/ICSI

It is very uncertain whether long‐term GnRH agonist therapy changes clinical pregnancy rate compared with no additional therapy (very low certainty).

1 finding from 1 review

Transdermal oestrogens vs oral oestrogens

Clinical pregnancy rate · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

Transdermal oestrogens showed no clear difference in clinical pregnancy rate compared with oral oestrogens (low certainty).

1 finding from 1 review

Starting administration of the progestogen earlier vs starting administration of the progestogen later

Clinical pregnancy rate · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

Starting administration of the progestogen earlier probably leads to higher clinical pregnancy rate compared with starting administration of the progestogen later (moderate certainty).

1 finding from 1 review

GnRH agonists vs placebo

Clinical pregnancy rate · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

It is very uncertain whether among different GnRH agonists changes clinical pregnancy rate compared with placebo (very low certainty).

1 finding from 1 review

Natural cycle vs programmed cycle

Clinical pregnancy rate · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

It is very uncertain whether natural cycle changes clinical pregnancy rate compared with programmed cycle (very low certainty).

1 finding from 1 review