Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

42 questions · 43 findings · 29 reviews

No studies found 2 · 4.7%GRADE not reported 0 · 0%Very low 15 · 34.9%Low 20 · 46.5%Moderate 6 · 14%High 0 · 0%

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · Women undergoing controlled ovarian stimulation in IVF and ICSI cycles (poor responders)

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonist or midcycle antagonist) (low certainty).

1 finding from 1 review

In vitro maturation vs in vitro fertilisation

Clinical pregnancy · subfertile women with polycystic ovarian syndrome undergoing assisted reproduction

It is very uncertain whether in vitro maturation changes clinical pregnancy compared with in vitro fertilisation (very low certainty).

1 finding from 1 review

Ultrasound‐guided embryo transfer vs clinical touch

Clinical pregnancies Number of clinical pregnancies per woman randomised · Women undergoing embryo transfer as part of IVF or ICSI cycle

Ultrasound‐guided embryo transfer probably leads to higher clinical pregnancy (per woman randomised) compared with clinical touch (moderate certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · for controlled ovarian stimulation

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonists or midcycle antagonist) (moderate certainty).

1 finding from 1 review

Metabolomics vs non metabolomics

Clinical pregnancy (Presence of a fetal heart on ultrasound scan at seven weeks of gestation) · Women undergoing IVF/ICSI cycles

Metabolomics showed no clear difference in clinical pregnancy (Presence of a fetal heart on ultrasound scan at… compared with non metabolomics (low certainty).

1 finding from 1 review

Metformin vs placebo or no treatment

Clinical pregnancy rate · women with polycystic ovary syndrome

It is very uncertain whether metformin changes clinical pregnancy rate per woman ‐ short protocol GnRH‐antagonist compared with placebo or no treatment (very low certainty).

1 finding from 1 review · compare the 2 reviews

Endometrial injury vs control

Clinical pregnancy per woman randomised: sensitivity analysis (no high‐risk) · women undergoing assisted reproduction

Endometrial injury showed no clear difference in clinical pregnancy per woman randomised: sensitivity analysis (no… compared with control (low certainty).

1 finding from 1 review