Findings

What do systematic reviews say?

126 questions · 127 findings · 45 reviews · Headline outcomes only

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No studies found 28 · 22%GRADE not reported 23 · 18.1%Very low 13 · 10.2%Low 24 · 18.9%Moderate 35 · 27.6%High 4 · 3.1%

Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection

Quality of Life: SF‐36 (physical component) · patients with adhesive capsulitis (frozen shoulder)

1 finding from 1 review

Manual therapy and exercise for adhesive capsulitis (frozen shoulder) 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 49 participants
Low

Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection

Quality of Life: SF‐36 (physical component) · patients with adhesive capsulitis (frozen shoulder)

1 finding from 1 review

Manual therapy and exercise for adhesive capsulitis (frozen shoulder) 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 49 participants
Low

BIFEPRUNOX vs placebo

Quality of life: Important change · patients with schizophrenia

1 finding from 1 review

Bifeprunox versus placebo for schizophrenia 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Inhaled corticosteroids vs placebo

Change in quality of life: SGRQ Scale: 0 to 100 · patients with stable chronic obstructive pulmonary disease

1 finding from 1 review

Inhaled corticosteroids versus placebo for stable chronic obstructive pulmonary disease 2023 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 2507 participants
Moderate

ZUCLOPENTHIXOL ACETATE vs placebo

Average change in quality of life/satisfaction · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Zuclopenthixol versus placebo for schizophrenia 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

ZUCLOPENTHIXOL DECANOATE vs placebo

Average change in quality of life/satisfaction · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Zuclopenthixol versus placebo for schizophrenia 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Zuclopenthixol dihydrochloride vs placebo

Average change in quality of life/satisfaction · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Zuclopenthixol versus placebo for schizophrenia 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease vs nil intervention, delayed intervention control, or placebo

Change in quality of life · treatment for asthma in adults and children with asthma and GORD

1 finding from 1 review

Pharmacological and surgical interventions for the treatment of gastro‐oesophageal reflux in adults and children with… 2021 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1595 participants
Low

Oral gabapentin vs placebo

Change in quality of life · adults with SMA types II and III

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 67 participants
Low

Oral hydroxyurea vs placebo

Change in quality of life · children and adults with SMA types II and III

The review found no eligible studies for this question.

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral olesoxime vs placebo

Change in quality of life · non‐ambulatory children and adolescents with SMA types II and III

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 108 participants
Low

Oral creatine vs placebo

Change in quality of life · children with SMA types II and III

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Low

Oral phenylbutyrate vs placebo

Change in quality of life · children with SMA type II

The review found no eligible studies for this question.

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Subcutaneous somatotropin vs placebo

Change in quality of life · children and adults with SMA types II and III

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
19 participants
Very low

Intravenous thyrotropin releasing hormone vs placebo

Change in quality of life · children with SMA types II and III

The review found no eligible studies for this question.

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral valproic acid plus acetyl‐L‐carnitine vs placebo

Change in quality of life · non‐ambulatory children with SMA types II and III

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 54 participants
Very low

Oral valproic acid vs placebo

Change in quality of life · ambulatory adults with SMA type III

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
28 participants
Moderate

Selective serotonin reuptake inhibitors vs placebo

Change in quality of life · chronic obstructive pulmonary disease (COPD) with depression

1 finding from 1 review

Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 148 participants
Very low

Tricylic antidepressant vs placebo

Change in quality of life · chronic obstructive pulmonary disease (COPD) with depression

1 finding from 1 review

Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Macrolides vs placebo

Quality of life: change · adults with bronchiectasis

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 305 participants
Low