Cochrane · systematic review · CD001496
Pharmacological and surgical interventions for the treatment of gastro‐oesophageal reflux in adults and children with asthma
Kopsaftis, Z, Yap, HS, Tin, KS, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
4
No studies
1
Included studies
NR
No studies 1 · 20%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 40%Moderate 2 · 40%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease compared to nil intervention, delayed intervention control, or placebo for asthma in adults and children
Population: treatment for asthma in adults and children with asthma and GORD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of participants with moderate/severe acute exacerbations Duration of treatment: range 24 weeks to 26 weeks Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease vs nil intervention, delayed intervention control, or placebo | OR 0.53 [0.17, 1.63] | 2 studies · 1168 participants | Low Downgraded: risk of bias |
Change in FEV₁ (L) Duration of treatment: range 6 weeks to 26 weeks Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease vs nil intervention, delayed intervention control, or placebo | no estimate extracted | 7 studies · 1333 participants | Moderate Downgraded: risk of bias |
Use of "rescue" medications and emergency action plans: B2 use puffs per day Duration of treatment: range 14 weeks to 24 weeks Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease vs nil intervention, delayed intervention control, or placebo | no estimate extracted | 2 studies · 239 participants | Moderate Downgraded: risk of bias |
Change in quality of life Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease vs nil intervention, delayed intervention control, or placebo | no estimate extracted | 5 studies · 1595 participants | Low Downgraded: risk of bias |
Healthcare utilisation ‐ not measured Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease vs nil intervention, delayed intervention control, or placebo | no estimate extracted | NR | No studies |