Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

11 questions · 11 findings · 8 reviews · Anaesthesia

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 27.3%Low 5 · 45.5%Moderate 2 · 18.2%High 1 · 9.1%

Beta‐blockers vs control—non‐cardiac surgery

All‐cause mortality (30 days)—non‐cardiac surgery · patients with conditions requiring non‐cardiac surgery

Beta‐blocker showed no clear difference in all‐cause mortality (30 days)—non‐cardiac surgery compared with control—non‐cardiac surgery (low certainty).

1 finding from 1 review

Beta‐blockers vs control—cardiac surgery

All‐cause mortality (30 days)—cardiac surgery · patients with coronary heart disease and/or valvular heart disease

Beta‐blocker showed no clear difference in all‐cause mortality (30 days)—cardiac surgery compared with control—cardiac surgery (moderate certainty).

1 finding from 1 review

Alpha2‐adrenergic agonist vs control

All‐cause mortality (within 30‐days after surgery: any reported death) · adults undergoing cardiac surgery

Alpha‐2 adrenergic agonists showed no clear difference in all‐cause mortality (within 30‐days after surgery: any reported death) compared with control (moderate certainty).

1 finding from 1 review

Epidural analgesia vs intravenous patient‐controlled analgesia

All‐cause mortality rate at 30 days · adults having abdominal surgery

Epidural analgesia showed no clear difference in all‐cause mortality rate at 30 days compared with intravenous patient‐controlled analgesia (low certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

All‐cause mortality (up to 30 days) · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in all‐cause mortality (up to 30 days) compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Early all‐cause mortality (within 30 days) · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

Perioperative beta‐blockers showed no clear difference in early all‐cause mortality (within 30 days) compared with placebo or standard care (low certainty).

1 finding from 1 review

Nitroglycerin vs no treatment

All‐cause mortality in 30 days post operation · patients (15 years of age and older) undergoing non‐cardiac surgery under any type of anaesthesia

It is very uncertain whether nitroglycerin changes all‐cause mortality in 30 days post operation compared with no treatment (very low certainty).

1 finding from 1 review

Nitroglycerin vs placebo

All‐cause mortality in 30 days post operation · patients (15 years of age and older) undergoing non‐cardiac surgery under any type of anaesthesia

It is very uncertain whether nitroglycerin changes all‐cause mortality in 30 days post operation compared with placebo (very low certainty).

1 finding from 1 review

Preoperative inspiratory muscle training vs usual care, non‐exercise intervention

Mortality In the early postoperative period (≤ 30 days) · adult participants undergoing cardiac and major abdominal surgery

It is very uncertain whether preoperative inspiratory muscle training changes all‐cause mortality within 30 days during postoperative period compared with usual care, non‐exercise intervention (very low certainty).

1 finding from 1 review