Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

20 questions · 20 findings · 11 reviews · Heart

No studies found 1 · 5%GRADE not reported 0 · 0%Very low 5 · 25%Low 6 · 30%Moderate 4 · 20%High 4 · 20%

Higher vs lower omega‐6: additional key outcomes

All‐cause mortality Study duration range 12‐96 months Omega‐6 dose range 1.5%‐24.5% E · adults with or without existing CVD

Higher showed no clear difference in all‐cause mortality Study duration range 12‐96 months Omega‐6 dose… compared with lower omega‐6: primary outcomes (low certainty).

1 finding from 1 review

clopidogrel plus aspirin vs aspirin

All‐cause mortality · people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease

clopidogrel plus aspirin showed no clear difference in all‐cause mortality compared with aspirin alone (low certainty).

1 finding from 1 review

Systematic screening vs no/opportunistic screening

All‐cause mortality · general population including those at moderate to high risk of CVD, mean age between 30 and 75

Systematic screening showed no clear difference in all‐cause mortality compared with no/opportunistic screening (low certainty).

1 finding from 1 review