Cochrane · systematic review · CD008093
Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death
Claro, JC, Candia, R, Rada, G, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 50%Low 5 · 35.7%Moderate 2 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Amiodarone compared to placebo or no treatment for high risk of Sudden Cardiac Death (primary prevention)
Population: participants with high risk of sudden cardiac death (primary prevention)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sudden cardiac death Amiodarone vs placebo or no treatment | RR 0.76 [0.66, 0.88] | 17 studies · 8383 participants | Low Downgraded: risk of bias, publication bias |
All‐cause mortality Amiodarone vs placebo or no treatment | RR 0.88 [0.78, 1] | 17 studies · 8383 participants | Low Downgraded: risk of bias, publication bias |
Amiodarone compared to beta blockers for high risk of sudden cardiac death (primary prevention)
Population: beta blockers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sudden cardiac death Amiodarone vs beta blockers | RR 0.37 [0.11, 1.22] | 2 studies · 342 participants | Low Downgraded: risk of bias, imprecision |
All‐cause mortality Amiodarone vs beta blockers | RR 0.27 [0.1, 0.75] | 2 studies · 342 participants | Low Downgraded: risk of bias, imprecision |
Amiodarone compared to other antiarrhythmics for high risk of sudden cardiac death (primary prevention)
Population: participants with high risk of sudden cardiac death (primary prevention)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sudden cardiac death Amiodarone vs other antiarrhythmics | RR 0.44 [0.19, 1] | 3 studies · 540 participants | Moderate Downgraded: risk of bias |
All‐cause mortality Amiodarone vs other antiarrhythmics | RR 0.37 [0.18, 0.76] | 3 studies · 540 participants | Moderate Downgraded: risk of bias |
Amiodarone compared to placebo or no treatment for high risk of sudden cardiac death (secondary prevention)
Population: participants with high risk of sudden cardiac death (secondary prevention)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sudden cardiac death Amiodarone vs placebo or no treatment | RR 4.32 [0.87, 21.49] | 2 studies · 440 participants | Very low Downgraded: imprecision, publication bias |
All‐cause mortality Amiodarone vs placebo or no treatment | RR 3.05 [1.33, 7.01] | 2 studies · 440 participants | Very low Downgraded: imprecision, publication bias |
Amiodarone compared to other antiarrhythmics for high risk of sudden cardiac death (secondary prevention)
Population: participants with high risk of sudden cardiac death (secondary prevention)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sudden cardiac death Amiodarone vs other antiarrhythmics | RR 1.4 [0.56, 3.52] | 4 studies · 839 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
All‐cause mortality Amiodarone vs other antiarrhythmics | RR 1.03 [0.75, 1.42] | 5 studies · 898 participants | Low Downgraded: risk of bias, imprecision |
Amiodarone compared to beta blockers for high risk of sudden cardiac death (secondary prevention)
Population: participants with high risk of sudden cardiac death (secondary prevention)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sudden cardiac death Amiodarone vs beta blockers | RR 0.84 [0.55, 1.27] | 1 study · 189 participants | Very low Downgraded: risk of bias, imprecision |
All‐cause mortality Amiodarone vs beta blockers | RR 0.96 [0.7, 1.32] | 1 study · 189 participants | Very low Downgraded: risk of bias, imprecision |
Amiodarone compared to sotalol for high risk of sudden cardiac death (secondary prevention)
Population: participants with high risk of sudden cardiac death (secondary prevention)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sudden cardiac death Amiodarone vs sotalol | RR 2.87 [0.32, 25.55] | 1 study · 45 participants | Very low Downgraded: risk of bias, imprecision |
All‐cause mortality Amiodarone vs sotalol | RR 1.08 [0.41, 2.83] | 2 studies · 104 participants | Very low Downgraded: risk of bias, imprecision |