Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

46 questions · 47 findings · 28 reviews

No studies found 5 · 10.6%GRADE not reported 0 · 0%Very low 23 · 48.9%Low 14 · 29.8%Moderate 5 · 10.6%High 0 · 0%

Intervention not reported

All‐cause mortality · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

The intervention showed no clear difference in all‐cause mortality (low certainty).

1 finding from 1 review

Sclerotherapy vs no intervention

All‐cause mortality · primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis

It is very uncertain whether sclerotherapy changes all‐cause mortality compared with no intervention (very low certainty).

1 finding from 1 review

Portosystemic shunts vs endoscopic intervention with or without medical treatment

All‐cause mortality · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether portosystemic shunts changes all‐cause mortality compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Distal splenorenal shunt vs endoscopic intervention

All‐cause mortality · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether distal splenorenal shunt changes all‐cause mortality compared with endoscopic intervention (very low certainty).

1 finding from 1 review

Transjugular intrahepatic portosystemic shunts vs endoscopic intervention with or without medical treatment

All‐cause mortality · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether transjugular intrahepatic portosystemic shunt changes all‐cause mortality compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Total shunt vs endoscopic intervention

All‐cause mortality · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether total shunt changes all‐cause mortality compared with endoscopic intervention (very low certainty).

1 finding from 1 review

Summary of findings table ‐ routine monitoring vs no routine monitoring of gastric residual

Mortality before hospital discharge · preterm infants

Summary of findings table ‐ routine monitoring showed no clear difference in all‐cause mortality before hospital discharge compared with no routine monitoring of gastric residual (low certainty).

1 finding from 1 review

Summary of findings table ‐ Re‐feeding vs discarding gastric residuals

Mortality before hospital discharge · preterm infants

Summary of findings table ‐ Re‐feeding showed no clear difference in all‐cause mortality before hospital discharge compared with discarding gastric residuals (low certainty).

1 finding from 1 review

Surgical portosystemic shunts vs devascularisation with splenectomy

All‐cause mortality · people with hepatosplenic schistosomiasis

It is very uncertain whether surgical portosystemic shunts changes all‐cause mortality compared with devascularisation with splenectomy (very low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality Median · adults older than 18 years, with no restriction regarding presence of ASCVD; participants generally had elevated risk of ASCVD (as…

The intervention showed no clear difference in all‐cause mortality Median (low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics

All‐cause mortality during hospital stay · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes all‐cause mortality during hospital stay compared with immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics (very low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs pentoxifylline with antibiotics and immunoglobulin M‐enriched intravenous immunoglobulin

All‐cause mortality during hospital stay · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes all‐cause mortality during hospital stay compared with pentoxifylline with antibiotics and immunoglobulin M‐enriched… (very low certainty).

1 finding from 1 review