Cochrane · systematic review · CD013176
Erythromycin prior to endoscopy for acute upper gastrointestinal haemorrhage
Adão, D, Gois, AFT, Pacheco, RL, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
28
current version
GRADE rated
25
No studies
3
Included studies
NR
No studies 3 · 10.7%Ungraded 0 · 0%Very low 23 · 82.1%Low 2 · 7.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Erythromycin versus placebo for acute upper gastrointestinal haemorrhage
Population: people with acute UGIH
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
UGIH‐related mortality Erythromycin vs placebo | no estimate extracted | 3 studies · 255 participants | Very low Downgraded: risk of bias, imprecision |
SAEs Erythromycin vs placebo | no estimate extracted | 3 studies · 255 participants | Very low Downgraded: risk of bias, imprecision |
All‐cause mortality Erythromycin vs placebo | RD 0 | 3 studies · 255 participants | Very low Downgraded: risk of bias, imprecision |
Visualisation of gastric mucosa Erythromycin vs placebo | no estimate extracted | 2 studies · 195 participants | Low Downgraded: risk of bias, imprecision |
NSAEs Erythromycin vs placebo | RD 0.01 | 3 studies · 255 participants | Very low Downgraded: risk of bias, imprecision |
Rebleeding Erythromycin vs placebo | RR 0.63 [0.13, 2.9] | 2 studies · 195 participants | Very low Downgraded: risk of bias, imprecision |
Blood transfusion Erythromycin vs placebo | no estimate extracted | 3 studies · 255 participants | Low Downgraded: risk of bias, imprecision |
Erythromycin plus nasogastric tube lavage versus no intervention/placebo plus nasogastric tube lavage for acute upper gastrointestinal haemorrhage
Population: people with acute UGIH
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
UGIH‐related mortality Erythromycin plus nasogastric tube lavage vs no intervention/placebo plus nasogastric tube lavage | no estimate extracted | 1 study · 29 participants | Very low Downgraded: risk of bias, imprecision |
SAEs Erythromycin plus nasogastric tube lavage vs no intervention/placebo plus nasogastric tube lavage | no estimate extracted | 6 studies · 408 participants | Very low Downgraded: risk of bias, imprecision |
All‐cause mortality Erythromycin plus nasogastric tube lavage vs no intervention/placebo plus nasogastric tube lavage | no estimate extracted | 3 studies · 238 participants | Very low Downgraded: risk of bias, imprecision |
Visualisation of gastric mucosa Erythromycin plus nasogastric tube lavage vs no intervention/placebo plus nasogastric tube lavage | no estimate extracted | 3 studies · 170 participants | Very low Downgraded: risk of bias, imprecision |
NSAEs Erythromycin plus nasogastric tube lavage vs no intervention/placebo plus nasogastric tube lavage | RD 0 | 6 studies · 408 participants | Very low Downgraded: risk of bias, imprecision |
Rebleeding Erythromycin plus nasogastric tube lavage vs no intervention/placebo plus nasogastric tube lavage | RR 1.13 [0.63, 2.02] | 1 study · 169 participants | Very low Downgraded: risk of bias, imprecision |
Blood transfusion Erythromycin plus nasogastric tube lavage vs no intervention/placebo plus nasogastric tube lavage | no estimate extracted | 3 studies · 180 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Erythromycin compared to nasogastric tube lavage for acute upper gastrointestinal haemorrhage
Population: people with acute UGIH
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
UGIH‐related mortality Erythromycin vs nasogastric tube lavage | no estimate extracted | 2 studies · 44 participants | Very low Downgraded: risk of bias, imprecision |
SAEs Erythromycin vs nasogastric tube lavage | no estimate extracted | 3 studies · 213 participants | Very low Downgraded: risk of bias, imprecision |
All‐cause mortality Erythromycin vs nasogastric tube lavage | RD 0.02 | 3 studies · 213 participants | Very low Downgraded: risk of bias, imprecision |
Visualisation of gastric mucosa Erythromycin vs nasogastric tube lavage | RR 1.19 [0.79, 1.79] | 2 studies · 198 participants | Very low Downgraded: risk of bias, imprecision |
NSAEs Erythromycin vs nasogastric tube lavage | no estimate extracted | 3 studies · 213 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Rebleeding Erythromycin vs nasogastric tube lavage | RR 0.77 [0.4, 1.49] | 1 study · 169 participants | Very low Downgraded: risk of bias, imprecision |
Blood transfusion Erythromycin vs nasogastric tube lavage | no estimate extracted | 1 study · 169 participants | Very low Downgraded: risk of bias, imprecision |
Erythromycin plus nasogastric tube lavage compared to metoclopramide plus nasogastric tube lavage for acute upper gastrointestinal haemorrhage
Population: people with acute UGIH
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
UGIH‐related mortality Erythromycin plus nasogastric tube lavage vs metoclopramide plus nasogastric tube lavage | no estimate extracted | NR | No studies |
SAEs Erythromycin plus nasogastric tube lavage vs metoclopramide plus nasogastric tube lavage | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision |
All‐cause mortality Erythromycin plus nasogastric tube lavage vs metoclopramide plus nasogastric tube lavage | no estimate extracted | NR | No studies |
Visualisation of gastric mucosa Erythromycin plus nasogastric tube lavage vs metoclopramide plus nasogastric tube lavage | RR 1.3 [0.86, 1.96] | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision |
NSAEs Erythromycin plus nasogastric tube lavage vs metoclopramide plus nasogastric tube lavage | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision |
Rebleeding Erythromycin plus nasogastric tube lavage vs metoclopramide plus nasogastric tube lavage | no estimate extracted | NR | No studies |
Blood transfusion Erythromycin plus nasogastric tube lavage vs metoclopramide plus nasogastric tube lavage | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision |