Findings

What do systematic reviews say?

85 questions · 86 findings · 24 reviews · Oral Health

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No studies found 19 · 22.1%GRADE not reported 55 · 64%Very low 10 · 11.6%Low 1 · 1.2%Moderate 1 · 1.2%High 0 · 0%

Advice about a healthy diet (including breastfeeding promotion and sugar avoidance) and feeding practices (e.g. relating to bottle-feeding and sleep) for infants and young children vs usual care

Adverse events for mother or child · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

1 finding from 1 review

Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood caries 2024 · Cochrane All outcomes
One trial only (Feldens 2007) provided information on adverse events and reported no events.
1 study
GRADE not reported

Package of oral health education/promotion including oral hygiene advice for pregnant women, mothers, infants and young children, plus dietary and feeding practice advice for infants and young children vs usual care

Adverse events for mother or child · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

1 finding from 1 review

Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood caries 2024 · Cochrane All outcomes
One trial (Harrison 2012) reported observing no adverse events; other trials provided no information on adverse events.
1 study
GRADE not reported

Prophylaxis (teeth cleaning) and CHX or iodine-NaF solution application in the dentition of women (mothers) vs placebo

Adverse events for mother or child · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age

1 finding from 1 review

Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood caries 2024 · Cochrane All outcomes
Two trials (Dasanayake 1993; Dasanayake 2002) reported adverse events related to topical application of the treatment solutions (other data).
2 studies
GRADE not reported

Psychological interventions vs no treatment

Adverse events · Children with a non-nutritive sucking habit (digit or pacifier)

1 finding from 1 review

Interventions for the cessation of non‐nutritive sucking habits in children 2015 · Cochrane All outcomes
SoF (psychological interventions vs no treatment): Adverse events - insufficient information reported. Table 3 (adverse outcomes after one month; Haryett 1967), psychological treatment group: reported upset 1/11 (9%);…
1 study
GRADE not reported

Any of the interventions (CR, SE, SW, sealing with sealant materials, Hall Technique, or NRCC) vs Each other, placebo, or no treatment

Adverse events (any type) and safety of sealant · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating cavitated or dentine carious lesions 2021 · Cochrane All outcomes
None of the studies reported adverse effects.
0 studies
No studies found

Ibuprofen taken pre-emptively (about 1 hour before treatment) vs Ibuprofen taken post-treatment

Adverse events · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
No studies in this comparison reported any adverse events.
0 studies
No studies found

Any surgical or non-surgical technique or material used for the treatment of post-extraction bleeding vs Placebo, no treatment, or another active antifungal intervention

Adverse events · People of any age and either gender with post-extraction bleeding, regardless of type of teeth (anterior or posterior, mandibular or…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating post‐extraction bleeding 2018 · Cochrane All outcomes
No data are available as no RCTs have been conducted on interventions to treat post-extraction bleeding
0 studies
No studies found

Intestinal trefoil factor (ITF), oral spray vs placebo

Adverse events · Adults receiving chemotherapy alone for colorectal cancer

1 finding from 1 review

Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes
Adverse events narratively reported (not GRADE-rated)
1 study
GRADE not reported

Low‐level laser therapy vs Placebo (sham) laser therapy

Adverse events · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for iatrogenic inferior alveolar and lingual nerve injury 2014 · Cochrane All outcomes
SoF row 'Adverse events': This outcome was not reported in the included studies.
0 studies
No studies found

PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

Adverse events associated with treatment · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
Adverse events: 22 surgical complications in the PET-CT group vs 83 in the planned-surgery group (Mehanna 2017).
1 study · 564 participants
Very low

Chlorhexidine gel (0.2%, intrasocket) vs placebo or no treatment

Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
No adverse events were reported. Six trials (673 participants) reported no adverse events from the use of chlorhexidine gel; one study (Rubio-Palau 2015) reported gastrointestinal discomfort (30, 18%), dizziness (10,…
7 studies
GRADE not reported

Chlorhexidine gel (0.2%, intrasocket) vs Chlorhexidine mouthrinse

Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
No adverse events were reported in these two trials (Abu-Mostafa 2015; Hita-Iglesias 2008).
2 studies
GRADE not reported

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) vs placebo or no treatment

Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
3 trials reported no adverse events. 1 study reported adverse events (alterations in taste, bad taste, staining) in 24/62 in chlorhexidine group versus 0/40 in placebo group, Peto OR = 8.42 (95% CI 3.31 to 21.39). A…
6 studies
GRADE not reported

Autologous platelet‐rich plasma vs placebo or no treatment

Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
No adverse events were reported in these two trials.
2 studies
GRADE not reported

Topical triamcinolone acetonide vs Cryotherapy

Adverse events (split-mouth) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide led to lower adverse events (split-mouth) compared with cryotherapy; GRADE not reported.

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
OR 0.01 [0.00, 0.16]
1 study · 30 participants
GRADE not reported

Mechanical tongue cleaning (tongue scraper) vs No tongue cleaning

Adverse events · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for managing halitosis 2019 · Cochrane All outcomes
mean 2 weeks
Adverse events: listed in the Summary of findings table but no data reported. No data were reported for adverse events.
0 studies
No studies found

Hinokitiol gel vs Placebo gel

Adverse events · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for managing halitosis 2019 · Cochrane All outcomes
mean 4 weeks
Adverse events: listed in the Summary of findings table but no data reported. No data were reported for adverse events.
0 studies
No studies found

Chlorhexidine + zinc acetate mouthwash vs Placebo mouthwash

Adverse events · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for managing halitosis 2019 · Cochrane All outcomes
mean 3 months
Adverse events: listed in the Summary of findings table but no data reported. No data were reported for adverse events.
0 studies
No studies found

Cetylpyridinium chloride mouthwash vs Chlorhexidine + zinc mouthwash

Adverse events · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

1 finding from 1 review

Interventions for managing halitosis 2019 · Cochrane All outcomes
2 weeks
Adverse events reported by Borden 2002 were not related to the interventions.
1 study · 44 participants
GRADE not reported

1000 mg champignon extract vs placebo

Adverse events · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for managing halitosis 2019 · Cochrane All outcomes
mean 2 weeks
Adverse events: listed in the Summary of findings table but no data reported. No data were reported for adverse events.
0 studies
No studies found