Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

12 questions · 12 findings · 7 reviews · Heart

No studies found 4 · 33.3%GRADE not reported 1 · 8.3%Very low 3 · 25%Low 1 · 8.3%Moderate 2 · 16.7%High 1 · 8.3%

Homocysteine‐lowering interventions (Folic Acid, Vitamin B6 and Vitamin B12) vs placebo or usual care

Adverse events · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… showed no clear difference in adverse events compared with placebo or standard care (high certainty).

1 finding from 1 review

Intervention not reported

Adverse events · adults (age 18 years or over) with myocardial infarction, stable angina, following coronary artery bypass graft surgery or percutaneous…

The review found no eligible studies for this question.

1 finding from 1 review