Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,228 questions · 1,245 findings · 383 reviews

No studies found 403 · 32.4%GRADE not reported 128 · 10.3%Very low 385 · 30.9%Low 232 · 18.6%Moderate 81 · 6.5%High 16 · 1.3%

Psychological therapy vs usual care or attention control

Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke

It is very uncertain whether psychological therapy changes adverse events: death ‐ at end of treatment (secondary outcome) compared with usual care and/or attention control (very low certainty).

1 finding from 1 review

Summary of findings. Surgery (percutaneous wire fixation) vs not surgery (cast only)

Serious adverse events (typically more serious complications) ( · children with displaced distal radius fracture with intact or involved or displaced ulna fracture (both‐bone fracture)

It is very uncertain whether summary of findings. Surgery (percutaneous wire fixation) changes serious adverse events (typically more serious complications) ( compared with not surgery (cast only) (very low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

Infants with possible related Severe Adverse Events ‐ 24 months11 · Breastfeeding infants of HIV‐infected mothers

It is very uncertain whether an extended NVP regimen administered to infants for 14 weeks changes infants with possible related Severe Adverse Events ‐ 24 months11 compared with sdNVP plus ZDV (1week) (very low certainty).

1 finding from 1 review

Irradiation with UV light: local narrow‐band UVB vs local PUVA

Primary: adverse events ‐ reported adverse events, mainly erythema · people with hand eczema unresponsive to clobetasol propionate

Irradiation with UV light: local narrow‐band UVB probably leads to higher primary: adverse events ‐ reported adverse events, mainly erythema compared with local PUVA (moderate certainty).

1 finding from 1 review

Oral retinoids: alitretinoin 30 mg vs placebo

Adverse effects: headache · people with moderate to severe chronic hand eczema

Oral retinoids: alitretinoin 30 mg leads to higher primary: adverse events ‐ headache Folluw‐up: 48 weeks to 72 weeks compared with placebo (high certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs an extended ZDV/3TC/ABC administered to mothers

Mothers with Severe Adverse Events Requiring Treatment Modification · HIV‐infected mothers and their breastfeeding infants

It is very uncertain whether an extended ZDV/3TC/LPV/r regimen administered to mothers changes mothers with Severe Adverse Events Requiring Treatment Modification compared with an extended ZDV/3TC/ABC administered to mothers (very low certainty).

1 finding from 1 review

Omega‐3 vs placebo

Adverse effects: neurological, extrapyramidal UKU (events) Medium‐term · people in the prodromal stage of psychosis

Group A: omega‐3 fatty acids showed no clear difference in adverse effects: neurological, extrapyramidal UKU (events) Medium‐term compared with placebo (low certainty).

1 finding from 1 review