Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

169 questions · 175 findings · 87 reviews · Headline outcomes only

No studies found 49 · 28%GRADE not reported 13 · 7.4%Very low 55 · 31.4%Low 41 · 23.4%Moderate 13 · 7.4%High 4 · 2.3%

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Rate of serious adverse events · adults (≥ 18 years of age) with a diagnosis of chronic heart failure with reduced ejection fraction (HFrEF)
2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Rate of serious adverse events · patients with chronic heart failure with preserved ejection fraction
2 findings from 1 review

Usual care vs immunosuppressive withdrawal after combination therapy

Serious adverse events · Participants with Crohn's disease in remission

It is very uncertain whether usual care changes serious adverse events compared with immunosuppressive withdrawal after combination therapy (very low certainty).

1 finding from 1 review

Usual care vs immunosuppressive withdrawal after monotherapy

Withdrawals due to adverse events · Participants with Crohn's disease in remission

It is very uncertain whether usual care changes withdrawal due to adverse events compared with immunosuppressive withdrawal after monotherapy (very low certainty).

1 finding from 1 review