Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

29 questions · 30 findings · 14 reviews

No studies found 9 · 30%GRADE not reported 0 · 0%Very low 11 · 36.7%Low 8 · 26.7%Moderate 2 · 6.7%High 0 · 0%

Summary of findings 1: blue‐light filtering lenses vs non blue‐light filtering IOL

Proportion of participants with adverse events with a probable causal link with the study interventions at six months · adults

Summary of findings 1: blue‐light filtering lenses may leads to lower proportion of participants with adverse events with a probable… compared with non‐blue‐light filtering lenses (low certainty).

1 finding from 1 review

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Adverse events during treatment · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Summary of findings for the main comparison: cough augmentation techniques vs no cough augmentation technique

Adverse events 1. Hypotensionc 2. Hypertensiond 3. Secretion encumbrance resulting in severe hypoxaemia requiring reintubationc · critically‐ill mechanically‐ventilated adults and children requiring extubation from mechanical ventilation

It is very uncertain whether summary of findings for the main comparison: cough augmentation… changes adverse events 1. Hypotensionc 2. Hypertensiond 3. Secretion… compared with no cough augmentation technique (very low certainty).

1 finding from 1 review

Zinc vs placebo

Adverse events number of participants hospitalised during the trial · children with cystic fibrosis

Summary of findings: Zinc supplementation showed no clear difference in adverse events number of participants hospitalised during the trial compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings: Inhaled antibiotics plus IV antibiotics vs IV antibiotics

Adverse events (moderate) · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

It is very uncertain whether summary of findings: Inhaled antibiotics plus IV antibiotics changes adverse events moderate adverse events experienced during and after… compared with IV antibiotics only (very low certainty).

1 finding from 1 review