Findings

What do systematic reviews say?

38 questions · 38 findings · 18 reviews · Headline outcomes only

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No studies found 11 · 28.9%GRADE not reported 3 · 7.9%Very low 8 · 21.1%Low 10 · 26.3%Moderate 6 · 15.8%High 0 · 0%

Hypertonic saline 7% vs hypertonic saline

Adverse events · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 3% to 7% vs Normal saline

Adverse events · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 142 participants
Very low

Hypertonic saline 3% to 7% vs Normal saline

Adverse events · adults and children with cystic fibrosis (stable lung disease)

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 513 participants
Low

Hypertonic saline vs Normal saline

Adverse events · people with bronchiectasis

Hypertonic saline showed no clear difference in adverse events compared with isotonic saline; GRADE not reported.

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
OR 8.2 [0.4, 169.9]
1 study · 40 participants
GRADE not reported

Saline vs carbon dioxide

Adverse events and complications · women undergoing outpatient hysteroscopy

Saline probably leads to lower adverse events and complications compared with carbon dioxide (moderate certainty).

1 finding from 1 review

Uterine distension media for outpatient hysteroscopy 2021 · Cochrane Headline outcomes only
Peto OR 0.53 [0.32, 0.86]
6 studies · 1076 participants
Moderate

Warm saline vs room temperature saline

Adverse events and complications · women undergoing outpatient hysteroscopy

1 finding from 1 review

Uterine distension media for outpatient hysteroscopy 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
GRADE not reported

Hypertonic saline vs rhDNase with

Adverse events · adults and children with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 47 participants
Very low

Hypertonic saline vs amiloride

Adverse events · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline vs sodium‐2‐mercaptoethane sulphonate (Mistabron®)

Adverse events · adults and children with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 29 participants
Very low

Hypertonic saline vs mannitol

Adverse events · adults and children with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Nebulised hypertonic saline vs nebulised 0.9% saline

Adverse events Assessed by investigators or reported by parents · infants up to 24 months of age with acute bronchiolitis

1 finding from 1 review

Nebulised hypertonic saline solution for acute bronchiolitis in infants 2023 · Cochrane Headline outcomes only
no estimate extracted
27 studies · 4416 participants
Low

Hypertonic saline 7% vs xylitol

Adverse events: serious adverse events · adults with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 89 participants
Very low

Sclerotherapy (hypertonic saline) vs sclerotherapy (any sclerosant)

Adverse events ‐ matting ( · people with telangiectasias and reticular veins

Sclerotherapy (hypertonic saline) showed no clear difference in adverse events ‐ matting ( compared with sclerotherapy (any sclerosant) (moderate certainty).

1 finding from 1 review

Treatment for telangiectasias and reticular veins 2021 · Cochrane Headline outcomes only
RR 0.89 [0.58, 1.36]
2 studies · 288 participants
Moderate

Sclerotherapy (hypertonic saline) vs sclerotherapy (any sclerosant)

Adverse events ‐ hyperpigmentation ( · people with telangiectasias and reticular veins

Sclerotherapy (hypertonic saline) probably leads to lower adverse events ‐ hyperpigmentation ( compared with sclerotherapy (any sclerosant) (moderate certainty).

1 finding from 1 review

Treatment for telangiectasias and reticular veins 2021 · Cochrane Headline outcomes only
RR 0.74 [0.59, 0.93]
2 studies · 288 participants
Moderate

Balanced crystalloid solutions vs Normal saline

Adverse events ‐ hypokalaemia · children with severe dehydration due to diarrhoea

Balanced crystalloid solutions probably leads to lower adverse events: hypokalaemia compared with 0.9% saline (moderate certainty).

1 finding from 1 review

Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children 2023 · Cochrane Headline outcomes only
RR 0.54 [0.31, 0.96]
Studies not reported
Moderate

Local corticosteroid injection (LCI) vs saline no treatment or placebo

Adverse events · carpal tunnel syndrome

1 finding from 1 review

Local corticosteroid injection versus placebo for carpal tunnel syndrome 2023 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 639 participants
Low

Polyhexamethylene biguanide (PHMB) vs Normal saline

Adverse events · people with venous leg ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Wound cleansing for treating venous leg ulcers 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Magnesium sulphate vs hypertonic saline

Adverse events · children up to 12 months old with acute bronchiolitis

The review found no eligible studies for this question.

1 finding from 1 review

Magnesium sulphate for treating acute bronchiolitis in children up to two years of age 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Magnesium sulphate + epinephrine vs no treatment or normal saline + epinephrine

Adverse events · children up to 12 months old with acute bronchiolitis

The review found no eligible studies for this question.

1 finding from 1 review

Magnesium sulphate for treating acute bronchiolitis in children up to two years of age 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: autologous serum vs Normal saline

Adverse events · people with dry eye

The review found no eligible studies for this question.

1 finding from 1 review

Autologous serum eye drops for dry eye 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found