Cochrane · systematic review · CD013640
Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children
Florez, ID, Sierra, J, Pérez-Gaxiola, G · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 12.5%Low 5 · 62.5%Moderate 2 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children
Population: children with severe dehydration due to diarrhoea
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time in hospital(days) Balanced crystalloid solutions vs 0.9% saline | no estimate extracted | NR | Moderate Downgraded: risk of bias |
Mortality (during hospitalization) Balanced crystalloid solutions vs 0.9% saline | RR 0.33 [0.02, 7.39] | NR | Very low Downgraded: risk of bias, imprecision |
Need for additional fluids Balanced crystalloid solutions vs 0.9% saline | RR 0.67 [0.26, 1.72] | NR | Low Downgraded: risk of bias, imprecision |
Total amount of fluids received Balanced crystalloid solutions vs 0.9% saline | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision |
Final pH after correction (corrected pH) Balanced crystalloid solutions vs 0.9% saline | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency |
Final bicarbonate level after correction Balanced crystalloid solutions vs 0.9% saline | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency |
Adverse events: hyponatraemia Balanced crystalloid solutions vs 0.9% saline | RR 1.41 [0.96, 2.07] | NR | Low Downgraded: risk of bias, imprecision |
Adverse events: hypokalaemia Balanced crystalloid solutions vs 0.9% saline | RR 0.54 [0.31, 0.96] | NR | Moderate Downgraded: imprecision |