Cochrane · systematic review · CD009327
Autologous serum eye drops for dry eye
Pan, Q, Angelina, A, Marrone, M, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
6
No studies
8
Included studies
NR
No studies 8 · 57.1%Ungraded 0 · 0%Very low 1 · 7.1%Low 5 · 35.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings: autologous serum compared with artificial tears
Population: participants with dry eye
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participant‐reported symptoms Range of scale: 0‐100, where a higher score is worse Summary of findings: autologous serum vs artificial tears | no estimate extracted | 1 study · 20 participants | Low Downgraded: risk of bias, imprecision |
Tear hyperosmolarity Summary of findings: autologous serum vs artificial tears | no estimate extracted | NR | No studies |
Fluorescein staining Range of scale: 0‐9, where a higher score is worse Summary of findings: autologous serum vs artificial tears | no estimate extracted | 1 study · 20 participants | Low Downgraded: risk of bias, imprecision |
Rose Bengal staining Range of scale: 0‐9, where a higher score is worse Summary of findings: autologous serum vs artificial tears | no estimate extracted | 1 study · 20 participants | Low Downgraded: risk of bias, imprecision |
Tear film break‐up time Summary of findings: autologous serum vs artificial tears | no estimate extracted | 1 study · 20 participants | Low Downgraded: risk of bias, imprecision |
Schirmer’s test Score < 4 mm indicates severe dry eye Summary of findings: autologous serum vs artificial tears | no estimate extracted | 1 study · 20 participants | Low Downgraded: risk of bias, imprecision |
Adverse events Summary of findings: autologous serum vs artificial tears | no estimate extracted | NR | No studies |
Summary of findings: autologous serum compared with saline
Population: participants with dry eye
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participant‐reported symptoms Summary of findings: autologous serum vs saline | no estimate extracted | NR | No studies |
Tear hyperosmolarity Summary of findings: autologous serum vs saline | no estimate extracted | NR | No studies |
Fluorescein staining Range of scale: 0‐9, where a higher score is worse Summary of findings: autologous serum vs saline | no estimate extracted | NR | No studies |
Rose Bengal staining Range of scale: 0‐9, where a higher score is worse Summary of findings: autologous serum vs saline | no estimate extracted | 1 study · 35 participants | Very low Downgraded: risk of bias |
Tear film break‐up time Summary of findings: autologous serum vs saline | no estimate extracted | NR | No studies |
Schirmer’s test Score < 4 mm indicates severe dry eye Summary of findings: autologous serum vs saline | no estimate extracted | NR | No studies |
Adverse events Summary of findings: autologous serum vs saline | no estimate extracted | NR | No studies |