Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

57 questions · 57 findings · 16 reviews · Gut

No studies found 25 · 43.9%GRADE not reported 3 · 5.3%Very low 18 · 31.6%Low 10 · 17.5%Moderate 1 · 1.8%High 0 · 0%

Prebiotic vs placebo

Withdrawals due to adverse events · people with histologically confirmed diagnosis of ulcerative colitis in remission

It is very uncertain whether prebiotics changes withdrawals due to adverse events (60 days to 6 months) compared with placebo (very low certainty).

1 finding from 1 review

Prebiotic vs placebo

Withdrawals due to adverse events · people with mild‐to‐moderate disease (Rachmilewitz index) or active disease (SCCAI score of 4 to 10)

It is very uncertain whether prebiotics changes withdrawals due to adverse events (14 days to 2 or 3 months) compared with placebo (very low certainty).

1 finding from 1 review

Duodenum‐preserving pancreatic resection vs pancreaticoduodenectomy

Adverse events (proportion) · people requiring surgery for chronic pancreatitis

It is very uncertain whether duodenum‐preserving pancreatic resection changes adverse events (proportion) compared with pancreaticoduodenectomy (very low certainty).

1 finding from 1 review

Duodenum‐preserving pancreatic resection vs pancreaticoduodenectomy

Adverse events (number of adverse events) · people requiring surgery for chronic pancreatitis

It is very uncertain whether duodenum‐preserving pancreatic resection changes adverse events (number of adverse events) compared with pancreaticoduodenectomy (very low certainty).

1 finding from 1 review

On‐demand deprescribing vs continued use

Adverse drug withdrawal events ‐ esophagitis (endoscopic findings) · people with moderate GERD and mild esophagitis, mean age 48 to 57 years

On‐demand deprescribing may leads to higher adverse drug withdrawal events ‐ esophagitis (endoscopic findings) compared with continued use (low certainty).

1 finding from 1 review

Abrupt discontinuation deprescribing vs continued use

Adverse drug withdrawal events ‐ relapse (endoscopic findings) · people with mild to moderate esophagitis, symptomatic, aged > 18 years (mean age 73 years)

It is very uncertain whether abrupt discontinuation deprescribing changes adverse drug withdrawal events ‐ relapse (endoscopic findings) compared with continued use (very low certainty).

1 finding from 1 review