It is very uncertain whether whole gland primary cryotherapy changes major adverse events compared with external beam radiotherapy (EBRT) (very low certainty).
Phytotherapy showed no clear difference in adverse events compared with placebo or other agents (low certainty).
Antibiotic therapy showed no clear difference in adverse events compared with placebo (moderate certainty).
Combination therapy showed no clear difference in adverse events compared with anticholinergics (moderate certainty).
Combination therapy probably leads to higher adverse events compared with placebo (moderate certainty).
Combination therapy showed no clear difference in adverse events compared with alpha‐blockers (low certainty).
Transurethral microwave thermotherapy probably leads to lower major adverse events compared with transurethral resection of the prostate (moderate certainty).
Targeted immunotherapy alone probably leads to lower adverse events (grade ≥ 3) compared with standard targeted therapies (moderate certainty).
Early taxane‐based chemotherapy and androgen deprivation therapy (ADT) may leads to higher all adverse events compared with ADT only (low certainty).
It is very uncertain whether convective radiofrequency water vapour thermal therapy changes major adverse events compared with sham procedure (very low certainty).
Extracorporeal shockwave therapy showed no clear difference in adverse events compared with control procedure (low certainty).
Early taxane‐based chemotherapy and androgen deprivation therapy (ADT) may leads to higher grade III to V adverse events compared with ADT only (low certainty).
Early taxane‐based chemotherapy and androgen deprivation therapy (ADT) may leads to higher discontinuation due to adverse events compared with ADT only (low certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.
Serenoa repens in combination with other phytotherapy showed no clear difference in adverse eventsCumulative incidence compared with placebo or no intervention (low certainty).