Cochrane · systematic review · CD012336
Anticholinergics combined with alpha‐blockers for treating lower urinary tract symptoms related to benign prostatic obstruction
Pang, R, Zhou, X-Y, Wang, X, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
UrologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
13
No studies
2
Included studies
NR
No studies 2 · 13.3%Ungraded 0 · 0%Very low 6 · 40%Low 5 · 33.3%Moderate 2 · 13.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Combination therapy versus placebo for treating lower urinary tract symptoms related to benign prostatic obstruction (short term)
Population: men with lower urinary tract symptoms related to benign prostatic obstruction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Urologic symptom scores Combination therapy vs placebo | no estimate extracted | 4 studies · 1792 participants | Low Downgraded: risk of bias, inconsistency |
QoL Combination therapy vs placebo | no estimate extracted | 2 studies · 991 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse events Combination therapy vs placebo | RR 1.24 [1.04, 1.47] | 3 studies · 1848 participants | Moderate Downgraded: imprecision |
AUR Combination therapy vs placebo | RR 1.94 [0.41, 9.08] | 5 studies · 2369 participants | Very low Downgraded: risk of bias, imprecision |
Surgical intervention – not reported Combination therapy vs placebo | no estimate extracted | NR | No studies |
Combination therapy versus alpha‐blockers for treating lower urinary tract symptoms related to benign prostatic obstruction (short term)
Population: men with lower urinary tract symptoms related to benign prostatic obstruction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Urologic symptom scores Combination therapy vs alpha‐blockers | no estimate extracted | 19 studies · 3631 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
QoL Combination therapy vs alpha‐blockers | no estimate extracted | 15 studies · 2687 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse events Combination therapy vs alpha‐blockers | RR 1.1 [0.9, 1.34] | 12 studies · 3561 participants | Low Downgraded: risk of bias, imprecision |
AUR Combination therapy vs alpha‐blockers | RR 2.03 [0.97, 4.23] | 19 studies · 4669 participants | Low Downgraded: risk of bias, imprecision |
Surgical intervention Combination therapy vs alpha‐blockers | RR 1.72 [0.34, 8.63] | 4 studies · 454 participants | Very low Downgraded: risk of bias, imprecision |
Combination therapy versus anticholinergics for treating lower urinary tract symptoms related to benign prostatic obstruction (short term)
Population: men with lower urinary tract symptoms related to benign prostatic obstruction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Urologic symptom scores Combination therapy vs anticholinergics | no estimate extracted | 2 studies · 710 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
QoL Combination therapy vs anticholinergics | no estimate extracted | 1 study · 56 participants | Low Downgraded: risk of bias, imprecision |
Adverse events Combination therapy vs anticholinergics | RR 1.26 [0.81, 1.95] | 1 study · 661 participants | Moderate Downgraded: imprecision |
AUR Combination therapy vs anticholinergics | RR 0.55 [0.11, 2.65] | 3 studies · 1178 participants | Low Downgraded: risk of bias, imprecision |
Surgical intervention – not reported Combination therapy vs anticholinergics | no estimate extracted | NR | No studies |