Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

919 questions · 933 findings · 245 reviews · Headline outcomes only

No studies found 314 · 33.7%GRADE not reported 51 · 5.5%Very low 303 · 32.5%Low 188 · 20.2%Moderate 65 · 7%High 12 · 1.3%

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Adverse events ‐ death in past 12 months (RR > 1 denotes higher risk of death) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether lay health worker‐led interventions for adult patients with harmful… changes adverse events ‐ deaths (RR < 1 denotes lower risk) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Interventions for involving older patients with multi‐morbidity in decision‐making about their health care vs usual care

Adverse event** Less patient involvement as a result of the intervention Not measured · older patients with multi‐morbidity

The review found no eligible studies for this question.

1 finding from 1 review

Surgical interventions (exploration and decompression / external neurolysis, internal neurolysis, neurorrhaphy / direct repair, neuroma excision, anastomosis, autologous or allograft nerve grafting or tubulization) vs conservative interventions

Serious adverse events · Children and adolescents with femoral shaft fractures

Surgical interventions may leads to higher serious adverse events compared with conservative interventions (low certainty).

1 finding from 1 review

Assistive technology for vision improvement interventions vs usual care or attention control

Adverse events Falls while switching glasses · Older people living in the community

Assistive technology for vision improvement interventions showed no clear difference in adverse events Falls while switching glasses compared with usual care or attention control (low certainty).

1 finding from 1 review