What do systematic reviews say?

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

The review found no eligible studies for this question.

• Interventions for central giant cell granuloma (CGCG) of the jaws 2009 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

The review found no eligible studies for this question.

• Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes
  No study reported any adverse events.
  0 studies
  No studies found

Psychological interventions vs no treatment

• Interventions for the cessation of non‐nutritive sucking habits in children 2015 · Cochrane All outcomes
  SoF (psychological interventions vs no treatment): Adverse events - insufficient information reported. Table 3 (adverse outcomes after one month; Haryett 1967), psychological treatment group: reported upset 1/11 (9%);…
  1 study
  GRADE not reported

Any experimental intervention (surgical or non-surgical) vs None (placebo or no treatment)

The review found no eligible studies for this question.

• Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Psychological intervention + orthodontic treatment (palatal crib or palatal arch) vs no treatment

• Interventions for the cessation of non‐nutritive sucking habits in children 2015 · Cochrane All outcomes
  Table 3 (adverse outcomes after one month; Haryett 1967), combined psychological plus orthodontic treatment group: reported upset 4/22 (18%); speech difficulty 6/22 (27%); eating difficulty 6/22 (27%); developing…
  1 study
  GRADE not reported

Any of the interventions (CR, SE, SW, sealing with sealant materials, Hall Technique, or NRCC) vs Each other, placebo, or no treatment

The review found no eligible studies for this question.

• Interventions for treating cavitated or dentine carious lesions 2021 · Cochrane All outcomes
  None of the studies reported adverse effects.
  0 studies
  No studies found

Any antimicrobial mouthwash and/or nasal spray (alone or in combination), at any concentration, delivered to healthcare workers, with or without the same intervention given to the patients with COVID-19 vs No treatment or saline or water

The review found no eligible studies for this question.

• Use of antimicrobial mouthwashes (gargling) and nasal sprays by healthcare workers to protect them when treating… 2020 · Cochrane All outcomes
  No data available (no included studies)
  0 studies
  No studies found

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes

  To 6 months
  Baysan 2003 stated that no adverse events were reported to 6 months; no information was provided by Abu-Naba'a 2003 or Abu-Naba'a 2003pilot.
  1 study
  GRADE not reported

Any surgical or non-surgical technique or material used for the treatment of post-extraction bleeding vs Placebo, no treatment, or another active antifungal intervention

The review found no eligible studies for this question.

• Interventions for treating post‐extraction bleeding 2018 · Cochrane All outcomes
  No data are available as no RCTs have been conducted on interventions to treat post-extraction bleeding
  0 studies
  No studies found

Low‐level laser therapy vs Placebo (sham) laser therapy

The review found no eligible studies for this question.

• Interventions for iatrogenic inferior alveolar and lingual nerve injury 2014 · Cochrane All outcomes
  SoF row 'Adverse events': This outcome was not reported in the included studies.
  0 studies
  No studies found

Hypnosis vs No hypnosis (no hypnotic intervention)

• Hypnosis for children undergoing dental treatment 2010 · Cochrane All outcomes
  None of the studies mentioned any adverse effects regarding hypnosis. (Gokli 1994; Trakyali 2008.)
  2 studies · 59 participants
  GRADE not reported

Prophylaxis (teeth cleaning) and CHX or iodine-NaF solution application in the dentition of women (mothers) vs placebo

• Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood caries 2024 · Cochrane All outcomes
  Two trials (Dasanayake 1993; Dasanayake 2002) reported adverse events related to topical application of the treatment solutions (other data).
  2 studies
  GRADE not reported

Package of oral health education/promotion including oral hygiene advice for pregnant women, mothers, infants and young children, plus dietary and feeding practice advice for infants and young children vs usual care

• Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood caries 2024 · Cochrane All outcomes
  One trial (Harrison 2012) reported observing no adverse events; other trials provided no information on adverse events.
  1 study
  GRADE not reported

Advice about a healthy diet (including breastfeeding promotion and sugar avoidance) and feeding practices (e.g. relating to bottle-feeding and sleep) for infants and young children vs usual care

• Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood caries 2024 · Cochrane All outcomes
  One trial only (Feldens 2007) provided information on adverse events and reported no events.
  1 study
  GRADE not reported

Chlorhexidine gel (0.2%, intrasocket) vs placebo or no treatment

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes

  Follow-up: median 7 days
  No adverse events were reported. Six trials (673 participants) reported no adverse events from the use of chlorhexidine gel; one study (Rubio-Palau 2015) reported gastrointestinal discomfort (30, 18%), dizziness (10,…
  7 studies
  GRADE not reported

Chlorhexidine gel (0.2%, intrasocket) vs Chlorhexidine mouthrinse

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes

  Follow-up: median 7 days
  No adverse events were reported in these two trials (Abu-Mostafa 2015; Hita-Iglesias 2008).
  2 studies
  GRADE not reported

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) vs placebo or no treatment

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes

  Follow-up: median 7 days
  3 trials reported no adverse events. 1 study reported adverse events (alterations in taste, bad taste, staining) in 24/62 in chlorhexidine group versus 0/40 in placebo group, Peto OR = 8.42 (95% CI 3.31 to 21.39). A…
  6 studies
  GRADE not reported

Autologous platelet‐rich plasma vs placebo or no treatment

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes

  Follow-up: median 7 days
  No adverse events were reported in these two trials.
  2 studies
  GRADE not reported

Mechanical tongue cleaning (tongue scraper) vs No tongue cleaning

The review found no eligible studies for this question.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  mean 2 weeks
  Adverse events: listed in the Summary of findings table but no data reported. No data were reported for adverse events.
  0 studies
  No studies found

Hinokitiol gel vs Placebo gel

The review found no eligible studies for this question.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  mean 4 weeks
  Adverse events: listed in the Summary of findings table but no data reported. No data were reported for adverse events.
  0 studies
  No studies found