It is very uncertain whether combination therapy changes serious adverse events compared with monotherapy (very low certainty).
Combination therapy showed no clear difference in adverse events compared with anticholinergics (moderate certainty).
Combination therapy probably leads to higher adverse events compared with placebo (moderate certainty).
Combination therapy showed no clear difference in adverse events compared with alpha‐blockers (low certainty).
Combination chemotherapy probably leads to higher toxicity ‐ early adverse events G3/4 compared with single‐agent chemotherapy (moderate certainty).
Combination of manual therapy and exercise probably leads to higher adverse events compared with glucocorticoid injection (moderate certainty).
Monotherapy showed no clear difference in adverse events compared with combination therapy (moderate certainty).
Combination showed no clear difference in overall serious adverse events compared with single‐form nicotine replacement therapy (low certainty).
Combination inhaled therapy probably leads to higher total adverse events compared with SABA alone (moderate certainty).
Combination of manual therapy and exercise following joint distension leads to lower adverse events compared with sham ultrasound following joint distension (high certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.
The review found no eligible studies for this question.
It is very uncertain whether combination with potassium‐sparing diuretics changes serious adverse events compared with monotherapy (very low certainty).
Combination of manual therapy, exercise, electrotherapy and oral NSAID may leads to higher adverse events Pain persisting longer than 2 hours after treatment… compared with oral NSAID (low certainty).
Serenoa repens in combination with other phytotherapy showed no clear difference in adverse eventsCumulative incidence compared with placebo or no intervention (low certainty).
Combination terbinafine plus azole showed no clear difference in adverse events compared with terbinafine monotherapy (low certainty).
Summary of findings 1: PLD with chemotherapy showed no clear difference in overall severe adverse events (grade ≥ 3) compared with alternative combination chemotherapy (moderate certainty).