Question · asked by 1 review
Combination terbinafine plus azole vs terbinafine: Adverse events
- Population
- participants with confirmed toenail onychomycosis
- Intervention
- Combination terbinafine plus azole
- Comparison
- terbinafine
- Outcome
- Adverse events
Combination terbinafine plus azole showed no clear difference in adverse events compared with terbinafine monotherapy (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Combination terbinafine plus azole vs terbinafine monotherapy Adverse events · participants with confirmed toenail onychomycosis Combination terbinafine plus azole showed no clear difference in adverse events compared with terbinafine monotherapy (low certainty). Oral antifungal medication for toenail onychomycosis (2017) · Cochrane Headline outcomes only | RR 0.64 [0.34, 1.21] | 1 study · 176 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Oral antifungal medication for toenail onychomycosis 2017 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.