Cochrane · systematic review · CD001284
Combined inhaled beta‐agonist and anticholinergic agents for emergency management in adults with asthma
Kirkland, SW, Vandenberghe, C, Voaklander, B, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 1 · 14.3%Moderate 5 · 71.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Combination inhaled therapy compared with SABA alone for acute asthma
Population: Adults with acute asthma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hospitalisation Combination inhaled therapy vs SABA alone | RR 0.72 [0.59, 0.86] | 16 studies · 2120 participants | Moderate Downgraded: risk of bias |
Total adverse events Combination inhaled therapy vs SABA alone | OR 2.03 [1.28, 3.2] | 11 studies · 1392 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
FEV₁ Combination inhaled therapy vs SABA alone | no estimate extracted | 6 studies · 687 participants | Low Downgraded: risk of bias |
Percent change FEV₁(%) Combination inhaled therapy vs SABA alone | no estimate extracted | 5 studies · 578 participants | Very low Downgraded: risk of bias |
Peak expiratory flow (PEF) Combination inhaled therapy vs SABA alone | no estimate extracted | 12 studies · 1056 participants | Moderate Downgraded: risk of bias |
Percent change from baseline PEF (%) Combination inhaled therapy vs SABA alone | no estimate extracted | 7 studies · 551 participants | Moderate Downgraded: risk of bias |
Relapse rates Combination inhaled therapy vs SABA alone | RR 0.8 [0.66, 0.98] | 5 studies · 1180 participants | Moderate Downgraded: risk of bias |