Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,199 questions · 1,226 findings · 451 reviews

No studies found 289 · 23.6%GRADE not reported 121 · 9.9%Very low 350 · 28.5%Low 279 · 22.8%Moderate 139 · 11.3%High 48 · 3.9%

Acetazolamide vs placebo

Adverse events: Paresthesias‐ Follow‐ up: From arrival to 24 hours later · participants at risk of high altitude illness

Acetazolamide may leads to higher adverse events: Paresthesias‐ Follow‐ up: From arrival to 24 hours… compared with placebo (low certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Serious adverse events, ‐ in total population randomised ‐ hypoglycaemia · critically ill patients

Intensive insulin therapy leads to higher serious adverse events, ‐ in total population randomised ‐… compared with conventional insulin therapy (high certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs conventional therapy

Adverse events (episodes of peritonitis) ‐ treated with an aminoglycoside · patients receiving PD

Angiotensin‐converting enzyme inhibitors (ACEi) showed no clear difference in adverse events (episodes of peritonitis) ‐ treated with an… compared with conventional therapy (moderate certainty).

1 finding from 1 review

Intervention not reported

Non‐serious adverse eventsClinical manifestation and laboratory examination · people with acute herpes zoster (within 7 days of onset of rash)

The intervention showed no clear difference in non‐serious adverse eventsClinical manifestation and laboratory… (low certainty).

1 finding from 1 review

Corticosteroids vs placebo compared

Serious adverse events (dichotomous data) ‐ suspected or probable pneumonia · critically ill patients

Corticosteroids showed no clear difference in serious adverse events (dichotomous data) ‐ suspected or probable… compared with placebo compared (high certainty).

1 finding from 1 review

Potassium citrate vs no intervention

Proportion of participants with adverse events while undergoing intervention · children with idiopathic urinary calculi treated with shockwave lithotripsy

It is very uncertain whether potassium citrate changes proportion of participants with adverse events while undergoing… compared with no intervention (very low certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs conventional therapy

Adverse events (episodes of peritonitis) ‐ not treated with an aminoglycoside · patients receiving PD

Angiotensin‐converting enzyme inhibitors (ACEi) showed no clear difference in adverse events (episodes of peritonitis) ‐ not treated with an… compared with conventional therapy (moderate certainty).

1 finding from 1 review

Exercise vs control immediately post intervention

Adverse events The timing of measurement was post‐intervention for all studies · people with multiple sclerosis

Exercise showed no clear difference in adverse events The timing of measurement was post‐intervention for… compared with control (post‐intervention) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Providing information about the residents? fall risk vs usual care

Serious adverse events related to the use of physical restraints ‐ not measured · older people in all long‐term care settings

The review found no eligible studies for this question.

1 finding from 1 review

Early warning systems (EWS) and rapid response systems (RRS) vs usual care

Adverse events (unexpected cardiac or respiratory arrest) – non‐randomised studies ( · adult on acute hospital wards at risk of clinical deterioration
2 findings from 1 review

5‐ASA vs control (all trials)

Number of participants with adverse events (epigastric pain, nausea, diarrhoea) · patients with the need for management of diverticulitis

5‐ASA showed no clear difference in number of participants with adverse events (epigastric pain, nausea,… compared with control (all trials) (moderate certainty).

1 finding from 1 review