Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,514 questions · 1,543 findings · 649 reviews

No studies found 224 · 14.5%GRADE not reported 105 · 6.8%Very low 383 · 24.8%Low 447 · 29%Moderate 293 · 19%High 91 · 5.9%

Antidepressants vs placebo

Serious adverse events between 0 and 16 weeks · predominantly knee osteoarthritis

Antidepressant showed no clear difference in serious adverse events between 0 and 16 weeks compared with placebo (low certainty).

1 finding from 1 review

L‐ornithine L‐aspartate vs placebo or no intervention

Serious adverse events assessed using ICH‐GCP

It is very uncertain whether L‐ornithine L aspartate changes serious adverse events assessed using ICH‐GCP compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Ocrelizumab vs placebo

Number of participants with any adverse events · primary progressive multiple sclerosis

Ocrelizumab probably leads to higher number of participants with any adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Azithromycin vs placebo or usual care

Serious adverse events during the study period · people with moderate to severe disease (WHO scale 4–9); all studies contributing results to the summary of findings table included people…

Azithromycin showed no clear difference in serious adverse events during the study period compared with placebo or standard of care alone (moderate certainty).

1 finding from 1 review