Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

106 questions · 107 findings · 49 reviews

No studies found 15 · 14%GRADE not reported 3 · 2.8%Very low 36 · 33.6%Low 25 · 23.4%Moderate 19 · 17.8%High 9 · 8.4%

Interferon beta‐1a vs placebo

Participants with 1 or more serious adverse events · patients with Guillain‐Barré syndrome

It is very uncertain whether interferon beta‐1a changes participants with 1 or more serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Corticosteroids vs control

Adverse events ‐ Diabetes mellitus requiring insulin · patients with Guillain‐Barré syndrome

Corticosteroid leads to higher adverse events ‐ diabetes mellitus requiring insulin compared with control (high certainty).

1 finding from 1 review

Intervention not reported

Adverse events leading to treatment discontinuation ( · adults and adolescents with pleural TB

The intervention may leads to higher adverse events leading to treatment discontinuation ( (low certainty).

1 finding from 1 review

Intervention not reported

Participants with non‐serious adverse events: up to 3 months' · participants with alcoholic hepatitis at high risk of mortality and morbidity

It is very uncertain whether the intervention changes participants with non‐serious adverse events: up to 3 months' (very low certainty).

1 finding from 1 review

Moderate‐potency vs mild‐potency topical corticosteroid

Local adverse events: skin thinning; end of treatment (2‐5 weeks) · children and adults with mild to severe eczema

Moderate‐potency may leads to lower local adverse events: skin thinning; end of treatment (2‐5 weeks) compared with mild‐potency topical corticosteroid (low certainty).

1 finding from 1 review

Very potent vs potent topical corticosteroid

Local adverse events: skin thinning; end of treatment (1 to 3 weeks) · adults with eczema

It is very uncertain whether very potent changes local adverse events: skin thinning; end of treatment (day 11‐day 22) compared with potent topical corticosteroid (very low certainty).

1 finding from 1 review

Intermittent 'as needed' ICS vs daily ICS

Patients with serious adverse health events (duration 12 to 52 weeks) · Children and adults with persistent asthma.

Intermittent 'as needed' ICS showed no clear difference in patients with serious adverse health events (duration 12 to 52 weeks) compared with daily ICS (low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse eventsClinical manifestation and laboratory examination · people with acute herpes zoster (within 7 days of onset of rash)

It is very uncertain whether the intervention changes serious adverse eventsClinical manifestation and laboratory… (very low certainty).

1 finding from 1 review

Moderate‐potency vs mild‐potency topical corticosteroid

Systemic adverse events: abnormal cortisol; end of treatment (1‐6 weeks) · children and adults with mild to severe eczema

It is very uncertain whether moderate‐potency changes systemic adverse events: abnormal cortisol; end of treatment (6‐28… compared with mild‐potency topical corticosteroid (very low certainty).

1 finding from 1 review

Intervention not reported

Non‐serious adverse eventsClinical manifestation and laboratory examination · people with acute herpes zoster (within 7 days of onset of rash)

The intervention showed no clear difference in non‐serious adverse eventsClinical manifestation and laboratory… (low certainty).

1 finding from 1 review