Cochrane · systematic review · CD010352
Ciclesonide versus other inhaled corticosteroids for chronic asthma in children
Kramer, S, Rottier, BL, Scholten, RJPM, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 44.4%Low 4 · 44.4%Moderate 1 · 11.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Ciclesonide versus budesonide (dose ratio 1:2) for chronic asthma in children
Population: patients with chronic asthma in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Asthma symptoms Asthma symptom score (scale 0 to 4) Ciclesonide vs budesonide (dose ratio 1:2) | no estimate extracted | 2 studies · 1024 participants | Low Downgraded: imprecision |
Patients with exacerbations Number of patients with exacerbations Ciclesonide vs budesonide (dose ratio 1:2) | RR 2.2 [0.75, 6.43] | 2 studies · 1024 participants | Very low Downgraded: imprecision |
Adverse events Number of patients with adverse events Ciclesonide vs budesonide (dose ratio 1:2) | no estimate extracted | 2 studies · 1024 participants | Low Downgraded: imprecision |
Ciclesonide versus fluticasone (dose ratio 1:1) for chronic asthma in children
Population: patients with chronic asthma in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Asthma symptoms Asthma symptom score (scale 0 to 4) Ciclesonide vs fluticasone (dose ratio 1:1) | no estimate extracted | 3 studies · 1468 participants | Moderate |
Patients with exacerbations Number of patients with exacerbations Ciclesonide vs fluticasone (dose ratio 1:1) | RR 1.37 [0.58, 3.21] | 2 studies · 1003 participants | Very low |
Adverse events Number of patients with adverse events Ciclesonide vs fluticasone (dose ratio 1:1) | no estimate extracted | 6 studies · 1560 participants | Low |
Ciclesonide versus fluticasone (dose ratio 1:2) for chronic asthma in children
Population: patients with chronic asthma in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Asthma symptom Asthma symptom score (scale 0 to 4) Ciclesonide vs fluticasone (dose ratio 1:2) | no estimate extracted | 1 study · 482 participants | Low Downgraded: imprecision |
Patients with exacerbations Number of patients with exacerbations Ciclesonide vs fluticasone (dose ratio 1:2) | RR 3.48 [1.35, 8.71] | 1 study · 502 participants | Very low Downgraded: imprecision |
Adverse events Number of patients with adverse events Ciclesonide vs fluticasone (dose ratio 1:2) | RR 0.99 [0.89, 1.08] | 1 study · 502 participants | Very low Downgraded: imprecision |