Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

93 questions · 93 findings · 48 reviews

No studies found 24 · 25.8%GRADE not reported 12 · 12.9%Very low 31 · 33.3%Low 18 · 19.4%Moderate 5 · 5.4%High 3 · 3.2%

Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID

Adverse events Pain persisting longer than 2 hours after treatment (during the 3‐week treatment period) · patients with adhesive capsulitis (frozen shoulder)

Combination of manual therapy, exercise, electrotherapy and oral NSAID may leads to higher adverse events Pain persisting longer than 2 hours after treatment… compared with oral NSAID (low certainty).

1 finding from 1 review

Summary of findings ‐ Erector spinae plane block vs serratus anterior plane block

Rates of block‐related adverse events · adults undergoing surgery with general anaesthesia

Summary of findings ‐ Erector spinae plane block showed no clear difference in rates of block‐related adverse events compared with serratus anterior plane block (low certainty).

1 finding from 1 review

Summary of findings ‐ Erector spinae plane block vs intercostal nerve block

Rates of block‐related adverse events · adults undergoing surgery with general anaesthesia

It is very uncertain whether summary of findings ‐ Erector spinae plane block changes rates of block‐related adverse events compared with intercostal nerve block (very low certainty).

1 finding from 1 review

Summary of findings ‐ Erector spinae plane block vs paravertebral block

Rates of block‐related adverse events · adults undergoing surgery with general anaesthesia

Summary of findings ‐ Erector spinae plane block probably leads to lower rates of block‐related adverse events compared with paravertebral block (moderate certainty).

1 finding from 1 review

Summary of findings ‐ Erector spinae plane block vs transversus abdominis plane block

Rates of block‐related adverse events · adults undergoing surgery with general anaesthesia

Summary of findings ‐ Erector spinae plane block showed no clear difference in rates of block‐related adverse events compared with transversus abdominis plane block (low certainty).

1 finding from 1 review

Oral paracetamol vs placebo

Patients with one or more adverse events · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local…

Paracetamol (single oral dose, any dose or formulation; subgroups up… showed no clear difference in patients with one or more adverse events compared with placebo; GRADE not reported.

1 finding from 1 review