Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,004 questions · 1,019 findings · 269 reviews

No studies found 333 · 32.7%GRADE not reported 106 · 10.4%Very low 313 · 30.7%Low 189 · 18.5%Moderate 66 · 6.5%High 12 · 1.2%

Acetaminophen plus Diphenhydramine vs placebo

Adverse events · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydramine led to lower adverse events compared with placebo; GRADE not reported.

1 finding from 1 review

Calcitonin (salmon calcitonin nasal spray 200 IU/day) vs placebo

Adverse events · Patients with histologically confirmed CGCG in one or both jaws and normal serum calcium and parathyroid hormone (PTH) levels
1 finding from 1 review
  • Adverse events were not described separately for each group. Trialists reported that adverse events were in most patients minimal and consisted of nausea, flushes and some dizziness. One patient had diarrhoea which…
    1 study · 14 participants
    GRADE not reported

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Adverse events · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Locking plate vs locking intramedullary nail

Adverse events: number of participants with complications · adults undergoing surgery for displaced proximal humeral fracturesa (2 trials)

It is very uncertain whether locking plate changes adverse events: number of participants with complications compared with locking intramedullary nail (very low certainty).

1 finding from 1 review

Reverse total shoulder arthroplasty (RTSA) vs hemiarthroplasty

Adverse events: number of participants with complications · adults undergoing surgery for displaced proximal humeral fracturesa (2 trials)

It is very uncertain whether reverse total shoulder arthroplasty (RTSA) changes adverse events: number of participants with complications compared with hemiarthroplasty (very low certainty).

1 finding from 1 review

Azathioprine vs methotrexate

Adverse event causing death or study drug discontinuation · adults with renal vasculitis for maintenance therapy

Azathioprine showed no clear difference in adverse events causing death or study drug discontinuation compared with methotrexate (low certainty).

1 finding from 1 review