Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

404 questions · 409 findings · 122 reviews

No studies found 77 · 18.8%GRADE not reported 31 · 7.6%Very low 142 · 34.7%Low 83 · 20.3%Moderate 63 · 15.4%High 13 · 3.2%

Summary of findings table ‐ Daratumumab plus standard therapy vs usual care

Adverse events (grade ≥ 3) · people with newly diagnosed multiple myeloma ineligible for transplant

Summary of findings table ‐ Daratumumab plus standard therapy showed no clear difference in adverse events (CTCAE grade ≥ 3) (longest available compared with standard therapy (moderate certainty).

1 finding from 1 review

Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs OnabotulinumtoxinA 20U

Major adverse events (eyelid ptosis, eyelid sensory disorder, strabismus) · glabellar lines

Summary of Findings Table ‐ AbobotulinumtoxinA 50U showed no clear difference in major adverse events ‐ Any major adverse events (eyelid ptosis,… compared with onabotulinumtoxinA 20U (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Oral small molecule inhibitors (apremilast or baricitinib) vs placebo

Incidence of serious adverse events · adults with alopecia areata

Summary of findings table ‐ Oral small molecule inhibitors… showed no clear difference in incidence of serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Summary of findings. Surgery (percutaneous wire fixation) vs not surgery (cast only)

Serious adverse events (typically more serious complications) ( · children with displaced distal radius fracture with intact or involved or displaced ulna fracture (both‐bone fracture)

It is very uncertain whether summary of findings. Surgery (percutaneous wire fixation) changes serious adverse events (typically more serious complications) ( compared with not surgery (cast only) (very low certainty).

1 finding from 1 review

Summary of findings 1: blue‐light filtering lenses vs non blue‐light filtering IOL

Proportion of participants with adverse events with a probable causal link with the study interventions at six months · adults

Summary of findings 1: blue‐light filtering lenses may leads to lower proportion of participants with adverse events with a probable… compared with non‐blue‐light filtering lenses (low certainty).

1 finding from 1 review

Summary of findings table ‐ CBT without antipsychotics vs antipsychotics

Risk for at least one adverse event per patient · schizophrenia

It is very uncertain whether summary of findings table ‐ CBT without antipsychotics changes adverse events ‐ Participants with at least one AE (separated time… compared with antipsychotics (very low certainty).

1 finding from 1 review

Summary of findings table ‐ CBT without antipsychotics vs CBT plus antipsychotics

Risk for at least one adverse event per patient · schizophrenia

Summary of findings table ‐ CBT without antipsychotics may leads to lower adverse events ‐ Participants with at least one AE (separated time… compared with CBT plus antipsychotics (low certainty).

1 finding from 1 review

Summary of findings table ‐ Daratumumab plus standard therapy vs usual care

Adverse events: infections (CTCAE grade ≥ 3) (longest available · people with newly diagnosed multiple myeloma ineligible for transplant

Summary of findings table ‐ Daratumumab plus standard therapy probably leads to higher adverse events: infections (CTCAE grade ≥ 3) (longest available compared with standard therapy (moderate certainty).

1 finding from 1 review

Psychosocial interventions vs inactive control

Adverse events (a count of reported harms or adverse events/experiences over life of study/ · survivors of sexual violence and abuse

It is very uncertain whether summary of findings table ‐ Psychosocial interventions changes adverse events (a count of reported harms or adverse… compared with inactive control (very low certainty).

1 finding from 1 review