Cochrane · systematic review · CD011915
Adjunctive therapies in addition to land‐based exercise therapy for osteoarthritis of the hip or knee
French, HP, Abbott, JH, Galvin, R · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
10
No studies
1
Included studies
NR
No studies 1 · 7.1%Ungraded 3 · 21.4%Very low 2 · 14.3%Low 6 · 42.9%Moderate 2 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy compared to placebo adjunctive therapies in addition to land‐based exercise therapy for osteoarthritis of the hip or knee
Population: osteoarthritis of the hip or knee
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs placebo adjunctive therapies | no estimate extracted | 22 studies · 1428 participants | Low Downgraded: inconsistency, publication bias |
Physical function Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs placebo adjunctive therapies | no estimate extracted | 20 studies · 1361 participants | Low Downgraded: inconsistency, publication bias |
Quality of life Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs placebo adjunctive therapies | no estimate extracted | 2 studies · 82 participants | Moderate Downgraded: imprecision, publication bias |
Participant‐reported global assessment Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs placebo adjunctive therapies | no estimate extracted | 0 studies · 0 participants | Ungraded |
Radiographic joint structure changes Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs placebo adjunctive therapies | no estimate extracted | 0 studies · 0 participants | Ungraded |
Adverse events Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs placebo adjunctive therapies | RR 2.41 [0.27, 21.9] | 2 studies · 340 participants | Low Downgraded: imprecision, inconsistency, publication bias |
Withdrawals due to adverse events Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs placebo adjunctive therapies | no estimate extracted | 0 studies · 0 participants | Ungraded |
Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy compared to land‐based exercise therapy for osteoarthritis of the hip or knee
Population: osteoarthritis of the hip or knee
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain ‐ total Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs land‐based exercise therapy | no estimate extracted | 41 studies · 3322 participants | Low Downgraded: inconsistency |
Physical function ‐ total Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs land‐based exercise therapy | no estimate extracted | 41 studies · 3323 participants | Very low Downgraded: inconsistency, publication bias |
Quality of life ‐ total Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs land‐based exercise therapy | no estimate extracted | 10 studies · 1483 participants | Very low Downgraded: risk of bias, inconsistency, publication bias |
Participant‐reported global assessment‐ total Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs land‐based exercise therapy | RR 1.37 [1.15, 1.62] | 5 studies · 840 participants | Moderate Downgraded: risk of bias, imprecision, publication bias |
Radiographic joint structure change (lower scores represent less joint structure change) Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs land‐based exercise therapy | no estimate extracted | 1 study · 156 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Adverse events Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs land‐based exercise therapy | RR 1.33 [0.78, 2.27] | 8 studies · 1542 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Withdrawals due to adverse events Summary of findings table ‐ Adjunctive therapies in addition to land‐based exercise therapy vs land‐based exercise therapy | no estimate extracted | NR | No studies |