Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

359 questions · 360 findings · 155 reviews · Headline outcomes only

No studies found 96 · 26.7%GRADE not reported 48 · 13.3%Very low 76 · 21.1%Low 83 · 23.1%Moderate 48 · 13.3%High 9 · 2.5%

Antidepressants vs placebo

Adverse effects during antidepressant treatment period (0‐12 weeks) · adults living with HIV and depression

It is very uncertain whether antidepressant changes adverse effects during antidepressant treatment period (0‐12 weeks) compared with placebo (very low certainty).

1 finding from 1 review

Pre‐hospital vs in‐hospital thrombolysis

Adverse effects ‐ bleeding complications · participants with ST‐elevation myocardial infarction

Pre‐hospital showed no clear difference in adverse effects ‐ bleeding complications compared with in‐hospital thrombolysis (moderate certainty).

1 finding from 1 review

Antidepressant plus antipsychotic vs placebo plus antidepressant

Acceptability ‐ dropouts due to adverse effects · adults with psychotic depression

The review found no eligible studies for this question.

2 findings from 1 review

Interferon vs placebo

Adverse effects during use of the preventative intervention (fever) ‐ pre‐ and postsurgical · participants with recurrent herpes labialis

Interferon showed no clear difference in adverse effects during use of the preventative intervention (fever)… compared with placebo (moderate certainty).

1 finding from 1 review

Lower blood pressure targets vs standard blood pressure targets

Withdrawals due to adverse events · cardiovascular disease with high blood pressure

It is very uncertain whether lower blood pressure targets changes participant withdrawals due to adverse effects compared with standard blood pressure targets (very low certainty).

1 finding from 1 review

Valaciclovir (suppressive regimen vs episodic regimen)

Adverse effects during use of the preventative intervention · participants with recurrent herpes labialis

It is very uncertain whether valaciclovir (suppressive regimen changes adverse effects during use of the preventative intervention compared with episodic regimen) (very low certainty).

1 finding from 1 review

Selective serotonin reuptake inhibitors vs tricyclic antidepressants (TCAs)

Adverse effects during antidepressant treatment period (0‐12 weeks) · adults living with HIV and depression

It is very uncertain whether selective serotonin reuptake inhibitors (SSRI) changes adverse effects during antidepressant treatment period (0‐12 weeks) compared with tricyclic antidepressant (TCA) (very low certainty).

1 finding from 1 review