Cochrane · systematic review · CD010191
Pre‐hospital versus in‐hospital thrombolysis for ST‐elevation myocardial infarction
McCaul, M, Lourens, A, Kredo, T · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 71.4%Moderate 1 · 14.3%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Pre‐hospital versus in‐hospital thrombolysis for ST‐elevation myocardial infarction
Population: participants with ST‐elevation myocardial infarction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause hospital mortality Pre‐hospital vs in‐hospital thrombolysis | RR 0.73 [0.37, 1.41] | 3 studies · 538 participants | Low Downgraded: risk of bias, imprecision |
Pre‐hospital versus in‐hospital thrombolysis for ST‐elevation myocardial infarction
Population: participants with ST‐elevation myocardial infarction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to thrombolytic treatment [minutes] Pre‐hospital vs in‐hospital thrombolysis | no estimate extracted | 2 studies · 438 participants | High |
Acute myocardial infarction functional outcomes ‐ ejection fraction [percentage] Pre‐hospital vs in‐hospital thrombolysis | no estimate extracted | 2 studies · 416 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects ‐ ventricular Fribrillation Pre‐hospital vs in‐hospital thrombolysis | RR 2.73 [0.68, 10.86] | 2 studies · 178 participants | Low Downgraded: imprecision |
Adverse effects ‐ bleeding complications Pre‐hospital vs in‐hospital thrombolysis | RR 0.88 [0.41, 1.92] | 2 studies · 438 participants | Moderate Downgraded: imprecision |
Adverse effects ‐ allergic reaction Pre‐hospital vs in‐hospital thrombolysis | RR 0 [0.19, 77.03] | 1 study · 100 participants | Low Downgraded: imprecision |
Adverse effects ‐ Stroke Pre‐hospital vs in‐hospital thrombolysis | RR 2.11 [0.39, 11.4] | 1 study · 360 participants | Low Downgraded: imprecision |