Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

321 questions · 347 findings · 123 reviews

No studies found 67 · 19.3%GRADE not reported 64 · 18.4%Very low 87 · 25.1%Low 60 · 17.3%Moderate 51 · 14.7%High 18 · 5.2%

Intervention not reported

Withdrawals due to adverse effects 5 years · Adults with mild hypertension and no cardiovascular disease

The intervention probably leads to higher withdrawals due to adverse effects 5 years (moderate certainty).

1 finding from 1 review

Etretinate vs PUVA

Proportion of participants with adverse effects serious or severe enough to have caused withdrawal ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

CBT vs no treatment or waiting list

Serious adverse effects at end of treatment · adults with tinnitus

CBT showed no clear difference in serious adverse effects at end of treatment compared with no intervention/waiting list control (moderate certainty).

1 finding from 1 review

RISPERIDONE vs placebo

Adverse events including extrapyramidal effects · terminally ill adults with delirium

Summary of findings: risperidone showed no clear difference in adverse events including extrapyramidal effectsd compared with placebo (low certainty).

1 finding from 1 review

Summary of findings: lorazepam plus haloperidol vs placebo plus haloperidol

Adverse events including extrapyramidal effects · terminally ill adults with severe delirium

It is very uncertain whether summary of findings: lorazepam plus haloperidol changes adverse events including extrapyramidal effectsd compared with placebo plus haloperidol (very low certainty).

1 finding from 1 review

HALOPERIDOL vs chlorpromazine

Adverse events including extrapyramidal effects · terminally ill adults with delirium

It is very uncertain whether summary of findings: haloperidol changes adverse events including extrapyramidal effectsc compared with chlorpromazine (very low certainty).

1 finding from 1 review

HALOPERIDOL vs lorazepam

Adverse events including extrapyramidal effects · terminally ill adults with delirium

It is very uncertain whether summary of findings: haloperidol changes adverse events including extrapyramidal effectsc compared with lorazepam (very low certainty).

1 finding from 1 review

HALOPERIDOL vs placebo

Adverse events including extrapyramidal effects · terminally ill adults with delirium

Summary of findings: haloperidol showed no clear difference in adverse events including extrapyramidal effectse compared with placebo (moderate certainty).

1 finding from 1 review

Ciprofloxacin vs fluoroquinolones

Adverse effects of treatment ‐ any adverse effects · patients with chronic bacterial prostatitis

Ciprofloxacin showed no clear difference in adverse effects of treatment ‐ any adverse effects compared with comparator fluoroquinolone (moderate certainty).

1 finding from 1 review

Levofloxacin vs fluoroquinolones

Adverse effects of treatment ‐ any adverse effects · patients with chronic bacterial prostatitis

Levofloxacin showed no clear difference in adverse effects of treatment ‐ any adverse effects compared with comparator fluoroquinolone (moderate certainty).

1 finding from 1 review

Levofloxacin vs ciprofloxacin

Adverse effects of treatment ‐ any adverse effects · patients with chronic bacterial prostatitis

Levofloxacin showed no clear difference in adverse effects of treatment ‐ any adverse effects compared with ciprofloxacin (moderate certainty).

1 finding from 1 review