What do systematic reviews say?

Phacoemulsification vs laser peripheral iridotomy

• Lens extraction versus laser peripheral iridotomy for acute primary angle closure 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 99 participants
  Low

Free spectacles vs no free spectacles (prescription only)

Free spectacles showed no clear difference in adverse effects compared with no free spectacles (prescription only) (moderate certainty).

• Vision screening for correctable visual acuity deficits in school‐age children and adolescents 2018 · Cochrane Headline outcomes only
  no estimate extracted
  0 participants
  Moderate

Acupuncture vs topical antibiotics plus warm compresses

The review found no eligible studies for this question.

• Acupuncture for acute hordeolum 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupuncture vs oral antibiotics plus warm compresses

The review found no eligible studies for this question.

• Acupuncture for acute hordeolum 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Vitrectomy vs scleral buckling

Pars plana vitrectomy (PPV) may leads to higher adverse effects (cataract development, choroidal detachment,… compared with scleral buckling (low certainty).

• Pars plana vitrectomy versus scleral buckling for repairing simple rhegmatogenous retinal detachments 2019 · Cochrane Headline outcomes only
  OR 1.71
  1 participants
  Low

Sharp‐edged intraocular lens (IOL) vs round‐edged IOL

It is very uncertain whether sharp‐edged intraocular lens (IOL) changes adverse effects compared with round‐edged IOL (very low certainty).

• Intraocular lens optic edge design for the prevention of posterior capsule opacification after cataract surgery 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Any prophylaxis vs no prophylaxis

It is very uncertain whether any prophylaxis changes adverse effects compared with no prophylaxis (very low certainty).

• Interventions for preventing ophthalmia neonatorum 2020 · Cochrane Headline outcomes only
  OR 0.93
  1993 participants
  Very low

Beta‐carotene vs placebo

• Antioxidant vitamin and mineral supplements for preventing age‐related macular degeneration 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  High

Vitamin C vs placebo

The review found no eligible studies for this question.

• Antioxidant vitamin and mineral supplements for preventing age‐related macular degeneration 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Multivitamin vs placebo

• Antioxidant vitamin and mineral supplements for preventing age‐related macular degeneration 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Moderate

NSAIDs vs steroids

• Prophylactic non‐steroidal anti‐inflammatory drugs for the prevention of macular oedema after cataract surgery 2016 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 488 participants
  GRADE not reported

NSAIDS plus steroids vs steroids

• Prophylactic non‐steroidal anti‐inflammatory drugs for the prevention of macular oedema after cataract surgery 2016 · Cochrane Headline outcomes only
  no estimate extracted
  18 studies · 18 participants
  GRADE not reported

Omega‐3 vs placebo

Omega 3 fatty acids leads to higher adverse effects compared with placebo (high certainty).

• Omega 3 fatty acids for preventing or slowing the progression of age‐related macular degeneration 2015 · Cochrane Headline outcomes only
  RR 1.01
  2 studies · 2343 participants
  High

Phototherapeutic keratectomy vs alcohol delamination

The review found no eligible studies for this question.

• Interventions for recurrent corneal erosions 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Therapeutic contact lens vs topical lubrication

The review found no eligible studies for this question.

• Interventions for recurrent corneal erosions 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Phototherapeutic keratectomy vs alcohol delamination

• Interventions for recurrent corneal erosions 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 33 participants
  Very low

Therapeutic contact lens vs topical lubrication

• Interventions for recurrent corneal erosions 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Vitamin E vs placebo

• Antioxidant vitamin and mineral supplements for preventing age‐related macular degeneration 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Vitamin A and fish oils (docosahexaenoic acid) vs placebo, vitamins, or no treatment

• Vitamin A and fish oils for preventing the progression of retinitis pigmentosa 2020 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 944 participants
  Very low