Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
SoF 3, Safety of the intervention over 3 months: systemic celecoxib (1 study) - 32 intervention participants reported 56 adverse effects, 20 placebo participants reported 20; 4 grade 3 events; 2 discontinued. Ketorolac…
2 studies
GRADE not reported
Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
SoF 5, Safety of the intervention up to 3 months: 'All patients in the bleomycin group developed erythema with erosion by the end of the applications, whereas erythema developed in the placebo group. Discomfort was…
1 study
GRADE not reported
Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
SoF 2, Safety of the intervention at 5 to 12 months: 'Systemic beta carotene did not cause any adverse effects in 1 study supplementing 10 mg/d (Nagao), and caused adverse effects of varying severity in 9% of…
3 studies
GRADE not reported
Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
SoF 1, Safety of the intervention at 4 to 12 months: '3 studies (1 each evaluating topical acitretin, topical 13-cis-retinoic acid, 200,000 IU per week of vitamin A) found no adverse effects. Systemic 13-cis-retinoic…
4 studies
GRADE not reported
Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
Adverse effects secondary to the intervention · women with aromatase inhibitor‐induced musculoskeletal symptoms (AIMSS)
1 finding from 1 review
Adverse effects: abnormal liver function tests · SSNS in children
It is very uncertain whether levamisole changes adverse effects: abnormal liver function tests compared with cyclophosphamide (very low certainty).
1 finding from 1 review
Discontinuation of medication due to adverse events · non‐immune adults and children travelling to or living in malaria‐endemic settings
Mefloquine led to higher discontinuation of drug due to adverse effects compared with atovaquone‐proguanil; GRADE not reported.
1 finding from 1 review
Number of participants reporting an adverse event · people with episodic migraine
Acupuncture showed no clear difference in number of participants reporting adverse effects compared with sham interventions (high certainty).
1 finding from 1 review
Number of participants reporting an adverse event · people with episodic migraine
Acupuncture probably leads to lower number of participants reporting adverse effects compared with prophylactic drugs (moderate certainty).
1 finding from 1 review
Nausea and vomiting · children with SCD who have been receiving prophylactic penicillin for at least two years
Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in adverse effects: incidences of nausea and vomiting compared with continuation (low certainty).
1 finding from 1 review
Adverse effects of any severity (systemic symptoms) · HIV‐positive and ‐negative adults and children
1 finding from 1 review
Adverse effects: toxic death (no definition provided) · children with cancer treated with platinum‐based therapy
Continuous platinum infusion showed no clear difference in adverse effects: toxic death (no definition provided) compared with bolus platinum infusion (low certainty).
1 finding from 1 review
Adverse effects: moderate to severe Infusion reactions · SSNS in children
Rituximab may leads to higher adverse effects: moderate to severe Infusion reactions compared with placebo or control (low certainty).
1 finding from 1 review
Adverse effects of epidural anaesthesia ‐ not reported · Patients undergoing thoracotomy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects (tooth staining and other side effects) · Children and adolescents aged 16 years or less
1 finding from 1 review
Gastrointestinal adverse events · patients (> 65 years) following hip fracture; patients with a recent stroke
It is very uncertain whether summary of findings table ‐ Protein changes side effects: at least one adverse gastrointestinal event compared with standard diet (very low certainty).
1 finding from 1 review
Adverse effects requiring withdrawal/discontinuation of study medication · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…
Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in side effects or other adverse events requiring withdrawal compared with placebo (placebo solution/mouthwash) (moderate certainty).
1 finding from 1 review
Intervention not reported
Adverse effects: bulging fontanelle within 48 to 72 hours · infants 1 to 6 months of age
The intervention leads to higher adverse effects: bulging fontanelle within 48 to 72 hours (high certainty).
1 finding from 1 review