Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

461 questions · 486 findings · 147 reviews

No studies found 150 · 30.9%GRADE not reported 114 · 23.5%Very low 100 · 20.6%Low 58 · 11.9%Moderate 57 · 11.7%High 7 · 1.4%

Systemic aminocaproic acid vs placebo

Adverse event nausea and vomiting (0 to 24 hours) · people with traumatic hyphema

Systemic aminocaproic acid probably leads to higher adverse effects: nausea or vomiting compared with placebo (moderate certainty).

1 finding from 1 review

UAE/UACE vs MTX

Adverse effects UAE vs systemic MTX · women with CSP

UAE/UACE showed no clear difference in adverse effects UAE vs systemic MTX compared with systemic MTX (low certainty).

1 finding from 1 review

Benzodiazepines (topical clonazepam) vs placebo

Adverse effects: euphoric behaviour · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether benzodiazepines (topical clonazepam) changes adverse effects: euphoric behaviour compared with placebo (very low certainty).

1 finding from 1 review

Laxative vs placebo

Adverse effects on babies: diarrhoea · women in the postpartum period

It is very uncertain whether laxative changes adverse effects on babies: diarrhoea compared with placebo (very low certainty).

1 finding from 1 review

Paromomycin ointment vs vehicle

Adverse effects Skin/local reactions · patients with Old World cutaneous leishmaniasis

It is very uncertain whether paromomycin ointment changes adverse effects Skin/local reactions compared with vehicle (very low certainty).

1 finding from 1 review

Adalimumab weekly vs placebo

Frequency of serious adverse effects · participants with hidradenitis suppurativa

Adalimumab weekly showed no clear difference in frequency of serious adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Adalimumab every other week vs placebo

Frequency of serious adverse effects · participants with hidradenitis suppurativa

Adalimumab every other week showed no clear difference in frequency of serious adverse effects compared with placebo (high certainty).

1 finding from 1 review

Exercise vs no intervention

Adverse effects associated with exercises Exercise programme duration: range 3 to 24 weeks · adults with ankylosing spondylitis

It is very uncertain whether exercise programmes changes adverse effects associated with exercises Exercise programme… compared with no intervention (very low certainty).

1 finding from 1 review

Antidepressants (trazodone 200 mg/day) vs placebo

Adverse effects: urinary incontinence · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether antidepressants (trazodone 200 mg/day) changes adverse effects: urinary incontinence compared with placebo (very low certainty).

1 finding from 1 review

Laser therapy vs Photodynamic therapy

Adverse effects ‐ All adverse effects · patients with dysphagia in oesophageal cancer

Laser showed no clear difference in adverse effects ‐ All adverse effects compared with photodynamic therapy (PDT) (moderate certainty).

1 finding from 1 review

SEMS vs laser

Adverse effects ‐ All adverse effects · patients with dysphagia in oesophageal cancer

SEMS showed no clear difference in adverse effects ‐ All adverse effects compared with laser (moderate certainty).

1 finding from 1 review