Cochrane · systematic review · CD005067
Interventions for Old World cutaneous leishmaniasis
Heras‐Mosteiro, J, Monge‐Maillo, B, Pinart, M, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
6
No studies
4
Included studies
NR
No studies 4 · 40%Ungraded 0 · 0%Very low 6 · 60%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsItraconazole (200 mg for 6 to 8 weeks) versus placebo for Old World cutaneous leishmaniasis
Population: patients with Old World cutaneous leishmaniasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Percentage of lesions cured after the end of treatment Itraconazole (200 mg for 6 to 8 weeks) vs placebo | no estimate extracted | NR | No studies |
Percentage of participants with complete cure Itraconazole (200 mg for 6 to 8 weeks) vs placebo | RR 3.7 [0.35, 38.99] | 3 studies · 244 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse effects Mild abdominal pain and nausea Adverse effects Mild abnormal liver function Itraconazole (200 mg for 6 to 8 weeks) vs placebo | RR 2.36 [0.74, 7.47] | 3 studies · 204 participants | Very low Downgraded: risk of bias, imprecision |
Speed of healing (time taken to be 'cured') Itraconazole (200 mg for 6 to 8 weeks) vs placebo | no estimate extracted | NR | No studies |
Microbiological or histopathological cure of skin lesions Itraconazole (200 mg for 6 to 8 weeks) vs placebo | RR 17 [0.47, 612.21] | 1 study · 20 participants | Very low Downgraded: risk of bias, imprecision |
Paromomycin ointment versus vehicle for Old World cutaneous leishmaniasis
Population: patients with Old World cutaneous leishmaniasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Percentage of lesions cured after the end of treatment Paromomycin ointment vs vehicle | no estimate extracted | NR | No studies |
Percentage of participants with complete cure Paromomycin ointment vs vehicle | RR 1 [0.86, 1.17] | 2 studies · 383 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Adverse effects Skin/local reactions Paromomycin ointment vs vehicle | RR 1.42 [0.67, 3.01] | 4 studies · 713 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Speed of healing (time taken to be 'cured') Paromomycin ointment vs vehicle | no estimate extracted | NR | No studies |
Microbiological or histopathological cure of skin lesions Paromomycin ointment vs vehicle | RR 1.03 [0.88, 1.2] | 2 studies · 383 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |