Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

403 questions · 428 findings · 117 reviews

No studies found 135 · 31.5%GRADE not reported 107 · 25%Very low 90 · 21%Low 44 · 10.3%Moderate 45 · 10.5%High 7 · 1.6%

Antidepressants (trazodone 200 mg/day) vs placebo

Adverse effects: urinary incontinence · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether antidepressants (trazodone 200 mg/day) changes adverse effects: urinary incontinence compared with placebo (very low certainty).

1 finding from 1 review

Laser therapy vs Photodynamic therapy

Adverse effects ‐ All adverse effects · patients with dysphagia in oesophageal cancer

Laser showed no clear difference in adverse effects ‐ All adverse effects compared with photodynamic therapy (PDT) (moderate certainty).

1 finding from 1 review

SEMS vs laser

Adverse effects ‐ All adverse effects · patients with dysphagia in oesophageal cancer

SEMS showed no clear difference in adverse effects ‐ All adverse effects compared with laser (moderate certainty).

1 finding from 1 review

Laxative vs placebo

Adverse effects on babies: loose stools · women in the postpartum period

It is very uncertain whether laxative changes adverse effects on babies: loose stools compared with placebo (very low certainty).

1 finding from 1 review

Amifostine vs no treatment/placebo

Adverse effects (other reported events) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review

Pilocarpine vs no treatment/placebo

Adverse effects (other reported events) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review

Summary of findings table ‐ Collagen vs standard diet or placebo

Adverse effects/events: at least 1 adverse effect ‐ as defined by individual studies. · adults with pressure ulcers

It is very uncertain whether summary of findings table ‐ Collagen changes side effects: at least one adverse event compared with standard diet or placebo (very low certainty).

1 finding from 1 review

Dietary supplements (Catuama herbal compound) vs placebo

Adverse effects: exacerbation of symptoms · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether dietary supplements (Catuama herbal compound) changes adverse effects: exacerbation of symptoms compared with placebo (very low certainty).

1 finding from 1 review

Laxative vs placebo

Adverse effects on women: abdominal cramps · women in the postpartum period

Laxative may leads to higher adverse effects on women: abdominal cramps compared with placebo (low certainty).

1 finding from 1 review

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Adverse effects: diabetes or hyperglycaemia · minimal change disease in adults with nephrotic syndrome

Calcineurin inhibitors ± oral steroids showed no clear difference in adverse effects: diabetes or hyperglycaemia compared with oral steroids alone (low certainty).

1 finding from 1 review

Combined HBO and perioperative antibiotics prior to dental implant therapy vs antibiotics alone

Adverse effects (including quality of life) · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
1 finding from 1 review

Group B antipsychotic drugs: amisulpiride + needs‐focused intervention vs needs‐focused intervention

Adverse effects: suicidal thoughts (events) · people in the prodromal stage of psychosis

It is very uncertain whether group B antipsychotic drugs: amisulpiride + needs‐focused intervention changes adverse effects: suicidal thoughts (events) compared with needs‐focused intervention (very low certainty).

1 finding from 1 review