Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

246 questions · 249 findings · 87 reviews · Headline outcomes only

No studies found 53 · 21.3%GRADE not reported 9 · 3.6%Very low 94 · 37.8%Low 53 · 21.3%Moderate 32 · 12.9%High 8 · 3.2%

Selective serotonin reuptake inhibitors vs tricyclic antidepressants (TCAs)

Acceptability ‐ total dropouts · patients with cancer and depression

It is very uncertain whether selective serotonin reuptake inhibitors (SSRIs) changes dropouts due to any cause (acceptability) compared with tricyclic antidepressants (TCAs) (very low certainty).

1 finding from 1 review

Intervention not reported

Acceptability · Various (pregnant women; daily smokers aged 16 and older; university students; children aged 5‐13)
1 finding from 1 review

Paroxetine vs placebo

Secondary outcome: acceptability of treatment · people with anxiety and comorbid alcohol use disorders

It is very uncertain whether paroxetine changes treatment acceptability compared with placebo (very low certainty).

1 finding from 1 review

Exercise vs control

Secondary outcome: acceptability of treatment · depression in adults
1 finding from 1 review
  • Exercise for depression 2013 · Cochrane Headline outcomes only
    no estimate extracted
    29 studies · 1363 participants
    Moderate

Mindfulness‐based 'third wave' cognitive and behavioural therapies vs ALL OTHER PSYCHOLOGICAL THERAPIES

Secondary outcome: acceptability of treatment · patients with depression

It is very uncertain whether mindfulness‐based 'third wave' cognitive and behavioural therapies changes treatment acceptability at compared with other psychological therapies (very low certainty).

1 finding from 1 review