Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

269 questions · 274 findings · 100 reviews

No studies found 58 · 21.2%GRADE not reported 27 · 9.9%Very low 96 · 35%Low 53 · 19.3%Moderate 32 · 11.7%High 8 · 2.9%

Valproate vs lithium

Dropout · Children and adolescents with acute mania

It is very uncertain whether valproate changes dropout rate ‐ All‐cause At 8 weeks (secondary acceptability outcome) compared with lithium (very low certainty).

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

Perazine showed no clear difference in acceptability of treatment Leaving the studies early due to any reason compared with other antipsychotics (low certainty).

1 finding from 1 review

PERPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

It is very uncertain whether comparison 1: PERPHENAZINE changes acceptability of treatment ‐ leaving the study early due to any reason compared with LOW‐POTENCY ANTIPSYCHOTIC DRUGS (very low certainty).

1 finding from 1 review

Systemic oral acyclovir vs placebo or no treatment

Patient or parental satisfaction (tolerance and acceptability of drug) · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
1 finding from 1 review
  • Amir 1997b: no data available. Ducoulombier 1988: tolerance and acceptability of the drug was described as satisfactory, but it was unclear how this was assessed by the trialists.
    1 study
    GRADE not reported

Maintenance treatment with antipsychotic drugs vs placebo/no treatment

Acceptability of treatment ‐ leaving the study early · schizophrenia

Maintenance treatment with antipsychotic drugs leads to lower leaving the study early: due to any reason (acceptability of… compared with placebo/no treatment (high certainty).

1 finding from 1 review

Valproate vs placebo

Dropout · Children and adolescents with acute mania

Valproate showed no clear difference in dropout rate ‐ All‐cause At 4‐6 weeks (secondary acceptability… compared with placebo (low certainty).

1 finding from 1 review

Valproate vs lithium

Dropout · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in dropout rate ‐ All‐cause At 2‐4 weeks (secondary acceptability… compared with lithium (moderate certainty).

1 finding from 1 review

Intervention not reported

Acceptability end of treatment (dropouts from study due to any reasons) · Patients with fibromyalgia

The intervention showed no clear difference in acceptability end of treatment (dropouts from study due to any… (low certainty).

1 finding from 1 review

CBT vs treatment

Acceptability (number of participants lost to post‐treatment assessment) · children and adolescents with anxiety disorders

CBT showed no clear difference in acceptability (number of participants lost to post‐treatment… compared with treatment (low certainty).

1 finding from 1 review

CBT vs WAIT LIST

Acceptability (number of participants lost to post‐treatment assessment) · children and adolescents with anxiety disorders

CBT showed no clear difference in acceptability (number of participants lost to post‐treatment… compared with waitlist (low certainty).

1 finding from 1 review

Valproate vs OLANZAPINE

Dropout · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in dropout rate ‐ All‐cause At 3‐12 weeks (secondary acceptability… compared with olanzapine (high certainty).

1 finding from 1 review

Antipsychotic dose increase vs antipsychotic dose continuation

Acceptability of treatment ‐ leaving the study early · non response in schizophrenia

Antipsychotic dose increase showed no clear difference in leaving the study early: acceptability ‐ leaving early due to any… compared with antipsychotic dose continuation (low certainty).

1 finding from 1 review

Psychological therapy vs Waitlist/Usual Care

Secondary outcome: acceptability of treatment · people with somatoform disorders and medically unexplained physical symptoms

Psychological therapy probably leads to lower acceptability 1 ‐ proportion of participants withdrawing during… compared with usual care or waiting list (moderate certainty).

1 finding from 1 review

Psychological therapy vs enhanced or structured care

Secondary outcome: acceptability of treatment · people with somatoform disorders and medically unexplained physical symptoms

Psychological therapy showed no clear difference in acceptability 1 ‐ proportion of participants withdrawing during… compared with enhanced or structured care (moderate certainty).

1 finding from 1 review