Findings

What do systematic reviews say?

19 questions · 19 findings · 6 reviews

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No studies found 3 · 15.8%GRADE not reported 0 · 0%Very low 6 · 31.6%Low 4 · 21.1%Moderate 6 · 31.6%High 0 · 0%

Tramadol vs no treatment or placebo

Pain · postoperative pain in preterm and term infants

The review found no eligible studies for this question.

1 finding from 1 review

Systemic opioids versus other analgesics and sedatives for postoperative pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Tramadol vs placebo

At least 30% reduction in pain · adults with neuropathic pain

1 finding from 1 review

Tramadol for neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 157 participants
Low

Tramadol vs placebo

At least 50% reduction in pain · adults with neuropathic pain

Tramadol may leads to higher at least 50% reduction in pain compared with placebo (low certainty).

1 finding from 1 review

Tramadol for neuropathic pain in adults 2017 · Cochrane Headline outcomes only
RR 2.2 [1.02, 4.6]
3 studies · 265 participants
Low

Tramadol vs pethidine

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

Tramadol showed no clear difference in number of patients with moderate to severe pain (PACU) compared with pethidine (low certainty).

1 finding from 1 review

Tramadol for postoperative pain treatment in children 2015 · Cochrane Headline outcomes only
RR 0.64 [0.36, 1.16]
2 studies · 94 participants
Low

Tramadol vs fentanyl

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

The review found no eligible studies for this question.

1 finding from 1 review

Tramadol for postoperative pain treatment in children 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Tramadol vs placebo

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

1 finding from 1 review

Tramadol for postoperative pain treatment in children 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Very low

Tramadol vs morphine

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

The review found no eligible studies for this question.

1 finding from 1 review

Tramadol for postoperative pain treatment in children 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Tramadol vs nalbuphine

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

1 finding from 1 review

Tramadol for postoperative pain treatment in children 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Very low

Tramadol vs paracetamol

Pain · patients with osteoarthritis

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Tramadol vs placebo

Pain · Patients with osteoarthritis of the knee or hip

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 3972 participants
Moderate

Tramadol vs NSAIDs

Pain · patients with osteoarthritis

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 952 participants
Moderate

Tramadol vs other opioids

Pain · patients with osteoarthritis

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 411 participants
Moderate

Oral tramadol vs oral morphine

Pain no worse than mild at one or two weeks (or equivalent) · people with cancer pain

1 finding from 1 review

Tramadol with or without paracetamol (acetaminophen) for cancer pain 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 227 participants
Very low

Oral tramadol vs oral morphine

At least 30% reduction in pain · people with cancer pain

1 finding from 1 review

Tramadol with or without paracetamol (acetaminophen) for cancer pain 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 227 participants
Very low

Oral tramadol vs oral morphine

At least 50% reduction in pain · people with cancer pain

1 finding from 1 review

Tramadol with or without paracetamol (acetaminophen) for cancer pain 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 227 participants
Very low

Tramadol in combination with acetaminophen vs NSAIDs

Pain · patients with osteoarthritis

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 226 participants
Moderate

Tramadol in combination with acetaminophen vs other opioids

Pain · patients with osteoarthritis

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 130 participants
Low

Tramadol in combination with acetaminophen vs placebo

Pain · patients with osteoarthritis

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 614 participants
Moderate

Dexketoprofen 25 mg plus tramadol 75 mg vs placebo

Participant‐reported pain relief of 50% or greater · adults with moderate or severe acute postoperative pain

1 finding from 1 review

Single fixed‐dose oral dexketoprofen plus tramadol for acute postoperative pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 748 participants
Moderate