Findings

What do systematic reviews say?

607 questions · 641 findings · 77 reviews

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No studies found 114 · 17.8%GRADE not reported 25 · 3.9%Very low 170 · 26.5%Low 175 · 27.3%Moderate 123 · 19.2%High 34 · 5.3%

Topical antibiotics with steroids vs placebo/no treatment

Suspected ototoxicity · chronic suppurative otitis media

1 finding from 1 review

Topical antibiotics with steroids for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 123 participants
Very low

Corticosteroids vs placebo or no treatment

Maternal death · women at risk of preterm birth

Maternal outcomes: corticosteroids showed no clear difference in maternal death compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth 2020 · Cochrane Headline outcomes only
RR 1.19 [0.36, 3.89]
Studies not reported
Moderate

Corticosteroids vs placebo or no treatment

Chorioamnionitis · women at risk of preterm birth

Maternal outcomes: corticosteroids showed no clear difference in chorioamnionitis№ of participants: 8374(15 RCTs) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth 2020 · Cochrane Headline outcomes only
RR 0.86 [0.69, 1.08]
Studies not reported
Moderate

Corticosteroids vs placebo or no treatment

Endometritis · women at risk of preterm birth

Maternal outcomes: corticosteroids showed no clear difference in endometritis№ of participants: 6764(10 RCTs) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth 2020 · Cochrane Headline outcomes only
RR 1.14 [0.82, 1.58]
Studies not reported
Moderate

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Oxygen requirement at 36 weeks' postmenstrual age · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) showed no clear difference in CLD at 36 weeks' PMA oxygen dependency at 36 weeks' PMA compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review

Early administration of inhaled corticosteroids for preventing chronic lung disease in very low birth weight preterm… 2017 · Cochrane Headline outcomes only
RR 0.97 [0.62, 1.52]
5 studies · 429 participants
Moderate

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36 weeks' PMA · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) probably leads to lower death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36… compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review

Early administration of inhaled corticosteroids for preventing chronic lung disease in very low birth weight preterm… 2017 · Cochrane Headline outcomes only
RR 0.86 [0.75, 0.99]
6 studies · 1285 participants
Moderate

Oral steroids vs control

Hearing loss · Children with otitis media with effusion

Summary of findings: oral steroids showed no clear difference in hearing loss [6 weeks] compared with control (moderate certainty).

1 finding from 1 review

Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
RR 1.09 [0.8, 1.49]
1 study · 44 participants
Moderate

Oral steroids vs control

OME resolution at short‐term · Children with otitis media with effusion

Summary of findings: oral steroids showed no clear difference in OME resolution at short‐term compared with control (moderate certainty).

1 finding from 1 review

Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
RR 3.8 [0.93, 15.52]
3 studies · 108 participants
Moderate

Oral steroids vs control

OME resolution at intermediate‐term · Children with otitis media with effusion

Summary of findings: oral steroids showed no clear difference in OME resolution at intermediate‐term compared with control (moderate certainty).

1 finding from 1 review

Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
RR 1.54 [0.76, 3.14]
3 studies · 106 participants
Moderate

Oral steroids vs control

OME resolution at long‐term · Children with otitis media with effusion

The review found no eligible studies for this question.

1 finding from 1 review

Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral steroids vs control

Symptoms · Children with otitis media with effusion

The review found no eligible studies for this question.

1 finding from 1 review

Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral steroids vs control

Adverse effects [4 to 6 weeks] · Children with otitis media with effusion

1 finding from 1 review

Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 143 participants
GRADE not reported

Glucocorticosteroids vs no intervention

Mortality at maximal · participants with alcoholic hepatitis (all severity)

It is very uncertain whether glucocorticosteroids changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 0.85 [0.67, 1.08]
12 studies · 1147 participants
Very low

Glucocorticosteroids vs no intervention

Early mortality (mortality up to 90 days) · participants with alcoholic hepatitis (all severity)

It is very uncertain whether glucocorticosteroids changes early mortality (mortality up to 90 days) compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1 [0.71, 1.39]
4 studies · 672 participants
Very low

Glucocorticosteroids vs no intervention

Mortality at maximal · participants with severe alcoholic hepatitis

It is very uncertain whether glucocorticosteroids changes mortality at maximal compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 0.88 [0.63, 1.21]
2 studies · 607 participants
Very low

Glucocorticosteroids vs no intervention

Early mortality (mortality up to 90 days) · participants with severe alcoholic hepatitis

It is very uncertain whether glucocorticosteroids changes early mortality (mortality up to 90 days) compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1.01 [0.71, 1.43]
2 studies · 607 participants
Very low

Glucocorticosteroids vs no intervention

Serious adverse events (proportion) · participants with severe alcoholic hepatitis

It is very uncertain whether glucocorticosteroids changes serious adverse events (proportion) compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1.37 [0.98, 1.93]
1 study · 546 participants
Very low

Glucocorticosteroids vs no intervention

Serious adverse events (number) · participants with severe alcoholic hepatitis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Glucocorticosteroids vs no intervention

Serious adverse events (proportion) · participants with alcoholic hepatitis (all severity)

It is very uncertain whether glucocorticosteroids changes serious adverse events (proportion) compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1.37 [0.98, 1.93]
1 study · 546 participants
Very low

Glucocorticosteroids vs no intervention

Health‐related quality of life · participants with severe alcoholic hepatitis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found