Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

213 questions · 220 findings · 27 reviews

No studies found 41 · 18.6%GRADE not reported 12 · 5.5%Very low 53 · 24.1%Low 90 · 40.9%Moderate 22 · 10%High 2 · 0.9%

Probiotics vs placebo

Relief of pain · Children with recurrent abdominal pain

Probiotics probably leads to higher improvement in pain: 0 to 3 months' postintervention Different… compared with placebo (moderate certainty).

2 findings from 1 review

Probiotics vs placebo

Improvement in pain: 0 to 3 months' postintervention Subgroup (irritable bowel syndrome) Different measures were used to assess improvement in pain, as above. · Children with recurrent abdominal pain

Probiotics probably leads to higher improvement in pain: 0 to 3 months' postintervention Subgroup… compared with placebo (moderate certainty).

1 finding from 1 review

Probiotics vs control

Systemic inflammatory response syndrome · patients with acute pancreatitis

It is very uncertain whether probiotics changes systemic inflammatory response syndrome compared with control (very low certainty).

1 finding from 1 review

Prophylactic probiotics vs placebo

Occurrence of new cases of colic Measured by: Wessel/Rome III Criteria · infants without colic

Prophylactic probiotics showed no clear difference in occurrence of new cases of colic Measured by: Wessel/Rome III Criteria compared with placebo (low certainty).

1 finding from 1 review

Prophylactic probiotics vs placebo

Adverse effects Measured by: reporting · infants without colic

Prophylactic probiotics showed no clear difference in adverse effects Measured by: reporting compared with placebo (low certainty).

1 finding from 1 review

Probiotics and osmotic laxative vs osmotic laxative

Global assessment of treatment success · children with chronic constipation without a physical explanation

Probiotics and osmotic laxative showed no clear difference in global improvement or treatment success, as defined by primary studies compared with osmotic laxative (low certainty).

1 finding from 1 review