Seizure freedom · absence seizures in children and adolescents
1 finding from 1 review
80% or greater reduction in seizure frequency ‐ not reported · absence seizures in children and adolescents
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
50% or greater reduction in seizure frequency · absence seizures in children and adolescents
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Normalisation of the EEG ‐ not reported · absence seizures in children and adolescents
It is very uncertain whether lamotrigine changes normalisation of the EEG compared with valproate (very low certainty).
1 finding from 1 review
Seizure freedom · patients with AD and epileptic seizures
It is very uncertain whether lamotrigine changes proportion with seizure freedom compared with phenobarbital (very low certainty).
1 finding from 1 review
Proportion with adverse events · patients with AD and epileptic seizures
It is very uncertain whether lamotrigine changes proportion with adverse events compared with phenobarbital (very low certainty).
1 finding from 1 review
50% or greater reduction in seizure frequency · patients with AD and epileptic seizures
It is very uncertain whether lamotrigine changes reduction in seizure frequency of 50% or more compared with phenobarbital (very low certainty).
1 finding from 1 review
Proportion with seizure freedom in dominantly inherited AD · patients with AD and epileptic seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Change in cognition · patients with AD and epileptic seizures
1 finding from 1 review
Change in neuropsychiatric symptoms · patients with AD and epileptic seizures
1 finding from 1 review
Improvement in quality of life · patients with AD and epileptic seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
50% or greater reduction in seizure frequency · people with drug‐resistant generalised tonic‐clonic seizures
Add‐on lamotrigine may leads to higher 50% or greater reduction in seizure frequency compared with placebo (low certainty).
1 finding from 1 review
Seizure freedom · people with drug‐resistant generalised tonic‐clonic seizures
It is very uncertain whether add‐on lamotrigine changes seizure freedom (i.e. total cessation of seizure activity) compared with placebo (very low certainty).
1 finding from 1 review
Treatment withdrawal · people with drug‐resistant generalised tonic‐clonic seizures
It is very uncertain whether add‐on lamotrigine changes treatment withdrawal compared with placebo (very low certainty).
1 finding from 1 review
Adverse effects · people with drug‐resistant generalised tonic‐clonic seizures
It is very uncertain whether add‐on lamotrigine changes adverse effects compared with placebo (very low certainty).
1 finding from 1 review
Seizure freedom · Lennox‐Gastaut syndrome, any age
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Number of participants with ≥ 75% reduction in all seizures · Lennox‐Gastaut syndrome, any age
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
50% or greater reduction in seizure frequency · Lennox‐Gastaut syndrome, any age
Lamotrigine plus ASMs leads to higher number of participants with ≥ 50% median reduction in all seizures compared with placebo plus ASMs (high certainty).
1 finding from 1 review
Number of participants with adverse events leading to study discontinuation · Lennox‐Gastaut syndrome, any age
Lamotrigine plus ASMs showed no clear difference in number of participants with adverse events leading to study… compared with placebo plus ASMs (low certainty).
1 finding from 1 review
50% or greater reduction in seizure frequency · people with drug‐resistant focal epilepsy
Summary of findings: lamotrigine probably leads to higher 50% or greater reduction in seizure frequency (ITT analysis) compared with placebo (moderate certainty).
1 finding from 1 review